Autoimmunity Flashcards

1
Q

What are auto-antibodies

A

antibodies generated by the immune system against the body’s own proteins, usually within cells

(the protein’s have been perceived by the body as alien and formed antibodies against them)

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2
Q

What causes the loss of regulation to cause auto-antibody production

A

It’s multi-factorial

  • genetic predisposition
  • environmental insults e.g. infection, prolonged chemical exposure
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3
Q

What is the effect of auto-antibodies on the body

A

they attack various organs and tissues, causing inflammation and damage

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4
Q

Anti-CCP antibody

A

Rheumatoid Arthritis

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5
Q

Anti-nuclear antibody (ANA)

A
SLE 
Sjogren's syndrome 
Systemic Sclerosis 
MCTD 
autoimmune liver disease
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6
Q

Anti-double stranded DNA antibody (dsDNA)

A

SLE

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7
Q

Anti-Sm antibody

A

SLE

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8
Q

Anti-Ro antibody

A

SLE

Sjogren’s syndrome

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9
Q

Anti-La antibody

A

Sjogren’s syndrome

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10
Q

Anti-centromere antibody

A

Systemic sclerosis (limited)

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11
Q

Anti-Scl-70-antibody

A

Systemic sclerosis (diffuse)

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12
Q

Anti-RNP antibody

A

SLE

MCTD

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13
Q

Anti-Jo-1 antibody

A

Myositis

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14
Q

Anti-cardiolipin antibody and lupus anticoagulant

A

Anti-phospholipid syndrome

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15
Q

Anti-neutrophil cytoplasmic antibody (ANCA)

A

Small vessel vasculitis (GPA, EGPA, MPA)

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16
Q

are false positives common in immunological testing

A

Yes!