Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

1. CLASP Alcohol > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What units can blood concentration be expressed as?

A 
mg of EtOH per 100ml of blood
in milliMolar (mM) units
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What does one unit =?

A

8g/10ml of ethanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the inhibitory targets of alcohol on the CNS?

A

glycine and GABAA receptors (cys-loop family)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the excitory targets of alcohol on the CNS?

A

acetylcholine and 5-HT3 receptors (cya-loop family)

subtypes of glutamate receptor (excitatory)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What causes CNS depression?

A

enhancement of inhibition and suppression of excitation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where can ethanol bind in the CNS?

A

intramembrane

extracellular domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What receptor subunits in the brain are involved in distinct aspects of the behavioural effects of ethanol that include reduction of anxiety, sedation and impaired motor coordination?

A

GABA alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which GABA subunit is synaptic and which is extrasynaptic?

A

synaptic - gamma

extra synaptic - delta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Where does Glutamate act?

A

ionotropic glutamate receptors (NMDA, AMPA and kainate subtypes)
GPCR glutamate receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name an NDMA antagonist that can fight the effects of addiction but give the same feelings?

A

ketamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the reward system in the CNS called?

A

mesolimbic dopaminergic pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where is dopamine released?

A

Ventral tegmental area (VTA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is the Ventral tegmental area (VTA) triggered?

A

signals from the Nucleus accumbens (NAc)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What drugs inhibit NAc neurones?

A

opioids
cannabinoids
PCP
ethanol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What drugs enhance dopamine release?

A

amphetamines

cocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What occurs in the brain in response to withdrawl?

A

upregulation of NMDA receptor expression in the brain and downregulation of GABBA alpha receptors

17
Q

What happens after an alcohol withdrawl?

A

There is an imbalance of excitory and inhibitory influences which causes anxiety, dysphoria and seizures

1. CLASP Alcohol (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions