Pharmacology Flashcards
ZERO ORDER KINETICS
WHAT PET
WHAT PET W - warfarin H - heparin A - aspirin T - tolbutamine P - phenytoin E - ethanol T - theophylline
cholinomimetic
for bowel and bladder atony
betanechol
adrenergic/ cholinergic synthesis inhibitor
cholinergic - hemicholinium
adrenergic - metyrosine
adrenergic/ cholinergic storage inhibitor
cholinergic - vesamicol
adrenergic - reserpine
tensilon test
Edrophonium
adrenergic/ cholinergic
blocks the release of Ach
cholinergic - botulinum
adrenergic - guanethedine
indirect cholinomimetics
Carbamates
Organophosphates
Neostigmine
DOC for organophosphate poisoning
1st - atropine
2nd - pralidoxime
Parkinson’s disease
muscarinic cholinergic antagonist
TRI to BIP the BENZ here.
trihexphenidyl
biperiden
benztropine
depolarizing neuromuscular blocker
succinylcholine
pag naka DEPOsit ka, SUCCESS yun
non-depolarizing neuromuscular blocker
tubucurarine
atracurium
organophosphate poisoning
DUMBBEELSS
DUMBBEELSS
diarrhea urination miosis bronchospasm bradycardia excitation emesis lacrimation sweating salivation
adrenergic metabolism inhibitor
MAOI, COMT
adrenergic reuptake inhibitor
cocaine, TCAs
pheochromocytoma
phenoxybenzamine
GINGIVA HYPERPLASIA
very nice cya phen!
very nice cya phen!
verapamil
nifedipine
cyclosporine
phenytoin
NARROW THERAPEUTIC INDEX
phen-phen WALA Car, Van Di To
phen-phen WALA Car, Van Di To
phenytoin phenobarbital warfarin aminoglycosides lithium amphotericin B Carbamazepine Vancomycin Digoxin Theophyllline
CLASS 1b antiarrhythmics
Phen, Lie To Me
Phen, Lie To Me
phenytoin
lidocaine
tocainide
mexiletene
amiodarone toxicity
PPT STC
PPT STC
Pulmonary fibrosis
paresthesia & Tremors
skin & corneal deposits
thyroid deficiency
DOC for paroxysmal SVT
adenosine
DOC for acute & chronic heart failure
acute - furosemide
chronic - ACEI
GYNECOMASTIA
Dig Spiral CAKe
Dig Spiral CAKE
digoxin spironolactone cimetidine alcohol ketoconazole
1st line of treatment for acute migraine and cluster headache attacks
SUMATRIPTAN (or other triptans)
serotonin receptor agonist
for antiemesis in patients post-chemotherapy or post-operation
ONDANSETRON (or other setron)
serotonin receptor antagonist
loop diuretics toxicity
OH DANG
OH DANG
ototoxicity hypokalemia dehydration allergy to sulfa nephritis gout
cutaneous flushing
VANC
VANC
vancomycin
adenosine
niacin
CCB
SE hemorrhagic cystitis
rescue: MESNA
cyclophosphamide
microtubule ihibitors
CV TAG
CV TAG
colchicine
vinca alkaloids
taxanes
azoles anti-helminthics
griseofulvin
amnesia & brain parts
anterograde - hippocampus
retrograde - thalamus
drugs for huntington disease
reserpine
tetrabenazine
drugs for tourette syndrome
haloperidol
pimozide
neuroleptic malignant syndrome
FEVER
FEVER
fever encephalopathy vitals unstable elevated CPK rigidity
manic symptoms
DIG FAST
DIG FAST
distractability irritability grandiosity flight of ideas agitation sleep/insomnia talkativeness
depression
5/8 symptoms for > 2 weeks
SIGE CAPS
SIGE CAPS
sleep interest - lack guilt/ worthlessness energy - lack concetration - lack appetite pyschomotor agitation suicide
TCA toxicity
3C
convulsion
coma
cardiotoxicity
serotonin syndrome
FAT CHD
FAT CHD
fever agitation tremor clonus hyperreflexia diaphoresis
malignant hyperthermia
FARTCH
FARTCH
Fever acidosis rhabdomyolysis trismus clonus hypertension
central vs nephrogenic DI
central - deficient secretion of ADH
nephrogenic - resistance with effects of ADH
DOC for acute asthma attacks
SABA
antidote for BB overdose
methylxanthines
DOC for asthma prophylaxis
corticosteroid
benzodiazepines
anticonvulsant
bipolar disorder
clonazepam
benzodiazepines
insomnia
estrazolam
filurazepam
triazolam
benzodiazepines
skel. m relaxation
diazepam
benzodiazepines
status epilepticus
lorazepam + diazepam
benzodiazepines
anesthesia induction
midazolam + diazepam
benzodiazepines
panic d/o or phobio
alprazolam + clonazepam
benzodiazepines
alcohol withdrawal
chlordiazepoxide + diazepam
anti-seizures
general tonic clonic seizure
VPA
PHE
CBZ
anti-seizures
partial seizures
LTG
PHE
CBZ
anti-seizures
absence seizures
ETX
VPA
anti-seizures
myoclonic & atypical absence
VPA
anti-seizures
Status epilepticUs
LZM (lorazepam)
DZM
PHE
Pbl (phenobarbital)
bipolar affective
VPA
CBZ
LTG
trigeminal neuralgia
CBZ
OXC
neuropathic pain (postherpetic neuralgia)
GBP
PGB
migraine
GBP
TPM
PHE
malignant hyperthermia
succinylcholine + halothane
for off-periods of parkinson’s disease
apomorphine
used in wearing-off phenomena of parkinson’s disease
entacapone, tolcapone
DOC for acute dystonia
Retrocollis
opisthotonus
oculogyric crisis
diphenydramine
DOC for parkinsonism
benztropine
DOC for rabbit syndrome
- perioral tremor
benztropine
DOC for akathisia
- restlessness, pacing, sitting up & down
diphenhydramine
DOC for neuroleptic malignant syndrome
3Ds
3Ds
dantrolene
diazepam
dopa agonists
only antipsychotic approved for schizophrenia in the youth
risperidone
only antipsychotic that reduces the risk of suicide
clozapine
SE ebstein’s anomaly
- displacement of right tricuspid valve
lithium
TCA overdose treatment
bicarbonate
erectile dysfunction
SORE PeniS can’t F* Hard
SORE PeniS can’t F* Hard
SSRI opiates respiridone ethanol, estrogen propanolol spironolacton finasteride hydrochlorthiazide
opioid of choice for pain relief in pancreatitis
meperidine
opioid overdose
naloxone
TX for hemochromatosis
for acute and chronic iron poisoning
deferoxamine
DOC for hypercholesterolemia (high LDL)
statin
HMG-CoA reductase
DOC for hypercholesterolemia (low HDL, High LDL/VLDL)
niacin
DOC for increasing HDL levels
niacin
CYP450 INDUCERS
ETHAN BARBS takes PHENPHEN & Refuses Greasy Carb Smoke
ETHAN BARBS takes PHENPHEN & Refuses Greasy Carb Smoke
ethanol barbiturate phenytoin rifampicin griseofulvin st. john's worth/ smoking
CYP450 INHIBITORS
Quin Ket E-CIGARS
Quin Ket E-CIGARS
Quinidine ketoconazole Erythromycin Cimetidine isoniazid grapefruit juice amiodarone ritonavir sulfonamides
DOC for anticoagulation during pregnancy
Heparin
DMARD of choice for RA
rescue agent: leucovorin (folinic acid)
methothrexate
1st line of treatment of chronic gout
allopurinol
GROWTH HORMONE
agonist
antagonist
agonist - SOMATROPIN
antagonist - OCREOTIDE
GONADOTROPINS
agonist
LH -LUTROPIN
FSH - FOLLITROPIN
MIXED - MENORTROPINS
PROLACTIN
antagonist
BROMOCRIPTINE (D2 ANTAGONIST)
GNRH
agonist
antagonist
agonist - GONADOTROPIN
antagonist - LEUPROLIDE
OXYTOCIN
antagonist
ATOSIBAN
VASOPRESSIN
agonist
antagonist
agonist - DESMOPRESSIN
antagonist - CONIVAPTAN
for GH deficiency in children & genetic disease with short stature (Turner, Prader-Willi)
somatropin
- GH agonist
for acroegaly, pituitary adenoma, carcinoid, gastrinoma, glucagonoma, variceal bleeding
ocreotide
- GH antagonist
DOC pregnant hyperthyroid patients
PTU
SE aplasia cutis congenita
methimazole & carbimazole
DOC for pregnany patients with cushing’s syndrome
metyrapone
as diagnostic test for adrenal function
metyrapone
- cushing’s syndrome
- medical abortion
mifepristone
emergency contraception
- must be taken within 72hours of unprotected sex
levonorgestrel
post-menopausal osteoporosis
raloxifen
denosumab
induction of ovulation in women who want to be pregnant
clomiphene
DOC syphilis
penicillin G
penicillin V
DOC gonorrhea
ceftriaxone & cefixime
AB to be avoided in pregnancy
fluoeoquinolones
DOC of candidiasis, coccidioidomycosis, cryptococcal meningitis
fluconazole
DOC blastomycosis, sporotrichosis, dermatophytosis esp onychomycosis, chromoblastomycosis
itraconazole
DOC asymptomatic cyst carrier in E. histolytica
diloxanide furoate
DOC trichomoniasis, bacterial vaginosis
metronidazole
DOC toxoplasmosis
pyrimethamine- sulfadiazine
DOC ascariasis, hookworm, pinworm, hydatid disease
mebendazole
DOC filariasis and eye worm disease (loa-loa)
diethylcarbamazine
DOC trichinosis
thiabendazole
DOC strongyloides
ivermectin
bactericidal
FV PAM
FV PAM
fuoroquinolones vancomycin penicillins aminoglycosides metronidazole
bacteriostatic
ECSTaTiC
ECSTaTiC
erythromycin clindamycin sulfamethoxazole trimethroprim tetracycline chloramphenicol
antipseudomonal penicillins
TCP - TC Pseudomonas
TCP
ticarcillin
Carbenicillin
piperacillin
extended spectrum penicillins
PHLEES
PHLEES
proteus mirabilis h. influenza Listeria monocytogenes e. coli enterococci salmonella sp.
first generation cephalosporin coverage
PEK first
PEK
Proteus mirabilis
e. coli
k. pneumonia
second generation cephalosporin coverage
HEN PEcKS
HEN PEcKS
h. influenza
e. coli
neisseria
proteus
enterobacter aerogenes
K. pneumonia
Serratia marcescens
PRIAPRISM
BuT Qa PAWiS
BuT Qa PAWiS
Buproprion Trazodone Quetiapine Papaverine Alprostadil Warfarin Sildenafil
only antipsychotic with fatal overdose
thirozidazine
most potent inhaled anesthetic
methoxyflurane
least potent inhaled anesthetic
Nitrous oxide
ONLY anti-seizure drug that affects K
OXC
ONLY anti-seizure drug that all (Na, Ca, GABA, Glutamate, Carbonic anhydrase)
TPM
delirium tremens
HAD48
HAD48
hallucinations
autonomic instability
delirium
48-72h post discontinuation
DOC benzodiazepine overdose
flumazenil
feto-renal damage
teratogen
ACE inhibitor
neural tube defects
teratogen
antiepileptic drugs
fetal hydantoin syndrome
teratogen
phenytoin
vaginal clear cell adenoCA
teratogen
DES
diethylstilbestrol
mobius sequence
teratogen
misoprostol
cutis laxa
teratogen
penicillamine
phocomelia
teratogen
thalidomide
ototoxicity
teratogen
streptomycin
kernicterus
teratogen
sulfonamides
cartilage damage
teratogen
fluoroquinolones
warfarin is teratogenic
what are the effects on 1st, 2nd & 3rd tri?
1st - chondrodysplasia
2nd - CNS malformations
3rd - bleeding diasthesis