Pharmacology Flashcards
Sympathetic pre-ganglionic neurotransmitter
ACh
Sympathetic post-ganglionic neurotransmitter
NA
Site of sympathetic outflow from the spinal cord
Thoraco-lumbar
Preganglionic neurones have … axons than postganglionic neurones
shorter
Parasympathetic pre-ganglionic neurotransmitter
ACh
Parasympathetic post-ganglionic neurotransmitter
ACh
Parasympathetic outflow from spinal cord
cranio-sacral
Sympathetic effects on the heart
increases HR, increases force of contraction
Sympathetic effects on the lungs
relaxes bronchi, reduces mucus production
Sympathetic effects on the GI tract
reduces motility and constricts sphincters
Sympathetic effects on the vasculature
constricts mostly, but relaxes in skeletal muscle
Sympathetic effects on the adrenal gland
release of adrenaline
Sympathetic effects on the penis
ejaculation
Parasympathetic effects on the heart
slows HR
Parasympathetic effects on the lungs
constricts bronchi and increases mucus
Parasympathetic effects on the GI tract
increases motility and relaxes sphincters
Parasympathetic effects on the vasculature
no effect
Parasympathetic effects on the adrenal glands
no effect
Parasympathetic effects on the penis
erection
Overview of neurotransmission (9points)
- Uptake of precursor
- Synthesis of transmitter
- Storage of transmitter in vesicle
- Causes depolarisation of AP
- Results in Ca2+ influx through voltage gated ion channels
- Calcium induced exocytosis of transmitter out of presynaptic ganglion
- Activation of G-proteins or ligand gated ion channels
- Reuptake of transmitter or
- Enzyme-mediated inactivation
