Pharmacology

Question 1

CYP450 Inducers

Answer 1

These drugs rev up CYP450 causing faster metabolism of drugs → ↓ drug effect

Chronic alcohol use
St. John's wort
Phenytoin
Phenobarbital
Nevirapine
Rifampin
Griseofulvin
Carbamazepine

“Chronic alcoholics Steal Phen-Phen and Never Refuse Greasy Carbs”

Question 2

CYP450 Inhibitors

Answer 2

These drugs slow down CYP450 causing slower metabolism of drugs → ↑ drug effects

Acute alcohol abuse
Ritonavir
Amiodarone
Cimetidine
Ketoconazole
Sulfonamides
Isoniazid (INH)
Grapefruit juice
Quinidine
Macrolides (except azithromycin)

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