*Pharmacology 4 (lecture 4) - only partially finished

Question 1

What drugs can be used to treat hypertension? (6)

Answer 1

Alpha blockers
ACEI
ARB
Beta blockers
Calcium channel antagonists
Thiazide like diuretic

Question 2

What do all beta blockers end in?

Answer 2

-olol

Question 3

What do ACEI end in?

Answer 3

-pril

Question 4

What do all ARB end in?

Answer 4

-artan

Question 5

What drugs can be used to treat angina? (6)

Answer 5

Beta blockers
Calcium antagonists
Nitrates
Nicorandil
Ivabradine
Ranolazine

Question 6

What are the 3 categories of anti-thrombotic drugs?

Answer 6

Anti-Platelet drugs
Anti-coagulants
Fibrinolytics

Question 7

What are 4 examples of anti-platlet drugs?

Answer 7

Aspirin
Clopidogrel
Prasugrel
Ticagrelor

Question 8

What are 3 examples of anti-coagulant drugs?

Answer 8

Warfarin
Rivaroxaban
Dabigatran

Question 9

What are 2 examples of fibrinolytic drugs?

Answer 9

Streptokinase

Tissue Plasminogen activator (tPA)

Question 10

What are 2 groups of anti-cholesterol drugs?

Answer 10

Statins

Fibrates

Question 11

What are the 5 main groups of CV drugs?

Answer 11

Anti-hypertensives
Anti-anginals
Anti-thrombotic
Anti-cholesterol
Anti-arrhythmics
(+others)

Question 12

How do diuretics work?

Answer 12

They block Na reabsorption in the kidneys and reduce the amount of fluid in the body

Question 13

What are the 2 categories of diuretics?

Answer 13

Thiazide like diuretics (mild)
Loop diuretics (stronger)

Question 14

Example of a thiazide like diuretic?

Used to treat?

Answer 14

Bendrofluazide

Hypertension

Question 15

Example of a loop diuretic?

Used to treat?

Answer 15

Furosemide

Heart failure

Question 16

Side effects of diuretics? (4)

Answer 16

Hypokalaemia (tired, arrhythmias)
Hyperglycaemia
Increased uric acid = gout
Impotence

Question 17

How do beta blockers work?

Answer 17

They block beta 1 +/- beta 2 adrenoceptors

Question 18

What is an example of a cardioselective beta blocker?

What is this used to treat? (3)

Answer 18

Atenolol
Angina
Hypertension
Heart failure

Question 19

What is an example of a non selective beta blocker?

What is it used to treat?

Answer 19

Propranolol

Thyrotoxicosis

Question 20

Contra-indication for use of beta blocker?

Answer 20

Asthma

Question 21

Side effects of beta blockers?

Answer 21

Asthma
Tiredness
Heart failure (good in the long term but can worsen it in the short term)
Cold peripheries

Question 22

2 types of calcium antagonists?

Answer 22

Dihydropyridines

Rate limiting calcium antagonists

Question 23

Example of a dihydropyridine?
What is used to treat? (2)
Side effects?

Answer 23

Amlodipine
Hypertension and angina
Ankle oedema

Question 24

2 examples of rate limiting calcium antagonists?
What are they used to treat?
What should these never be used with?

Answer 24

Verapamil, Dilitiazem
Hypertension, angina, SV arrhythmias
Beta blockers

Question 25

How do alpha blockers work?

Answer 25

Block alpha adrenoceptos to cause vasodialtion

Question 26

What are alpha blockers used to treat?

Answer 26

hypertension

Prostatic hypertrophy

Question 27

Example of alpha blocker?

Side effects?

Answer 27

Doxazosin

Postural hypotension

Question 28

How do ACEI work?

Answer 28

Block angiotensin I from becoming angiotensin II

Question 29

Example of an ACEI?

Answer 29

Lisinopril

Question 30

What are ACEI used for?

Answer 30

Hypertension and heart failure

Question 31

In terms of the kidneys what is ACEI good and bad for?

Answer 31

Good for diabetic nephropathy

Bad for renal artery stenosis