Pharmacology

Question 1

MOA of Methotrexate

Answer 1

An antimetabolite which inhibits dihydrofolate reductase

Question 2

MOA of Ciclosporin

Answer 2

immunosuppressant which decreases clonal proliferation of T cells by reducing IL-2 release. It acts by binding to cyclophilin forming a complex which inhibits calcineurin, a phosphatase that activates various transcription factors in T cells

Special note:
Side effects - Everything is high

Question 3

Drugs exhibiting zero order kinetics

Answer 3

phenytoin
salicylates (e.g. high-dose aspirin)
heparin
ethanol

Question 4

Drugs affected by Acetylator status

Answer 4

isoniazid
procainamide
hydralazine
dapsone
sulfasalazine

Question 5

CD20 monoclonal antibody

Answer 5

Rituximab

CD20 is expressed on B cells.

Screen for Hepatitis B before use

Question 6

Natalizumab

Answer 6

a monoclonal antibody that targets α4-integrin.

Used in treatment of Multiple sclerosis and Crohn’s disease

Screen for Progressive multifocal leukoencephalopathy before use

Question 7

TNF Inhibitors: Infliximab/Etanecept

Answer 7

Monoclonal antibody targeting TNF alpha.

Screen for Tuberculosis before use