Pharmacology

Question 1

Beta blocker SEs

Answer 1

Sleep disturbance
ED
Fatigue/cold peripheries/bronchospasm

Question 2

Drugs that worsen HF?

Answer 2

NSAIDs

Question 3

Drugs that cause sweating?

Answer 3

Antidepressants

Question 4

Antibiotics safe in breastfeeding

Answer 4

Penicillins
Cephalosporins
Trimethoprim

Question 5

Drugs that can lower BNP levels

Answer 5

ACE-Is
ARBs
Diuretics
Beta blockers
Obesity

Question 6

RA drug causing oligospermia

Answer 6

Sulpfasalazine

Question 7

How does bioavailability of ACE-Is change with age?

Answer 7

Reduces - first-pass metabolism reduces with age and ACE-Is are pro-drugs (except lisinopril and captopril)

Question 8

Drug that precipitates in syringe drivers

Answer 8

Metoclopramide
Cyclizine

Question 9

Drugs that cause gout

Answer 9

Thiazides
Loop diuretics

Question 10

Rheum drug causing retinopathy

Answer 10

Hydroxychloroquine —> annual vision check

Question 11

Common P450 inhibitors

Answer 11

ciprofloxacin, erythromycin
omeprazole
allopurinol
antifungals
SSRIs
valproate

Question 12

Phenytoin side effects

Answer 12

Overgrowth of hair, gums, face
Peripheral neuropathy + megaloblastic anaemia (folate metabolism)

Question 13

When to stop COCP before major surgery

Answer 13

4 weeks
Offer POP until mobile

Question 14

Best Parkinson’s treatment in Parkinsons-related dementia

Answer 14

Rivastigmine

Question 15

Side effect of AChE inhibitors (DRG)

Answer 15

Bradycardia

Question 16

Thiazide electrolyte abnormality

Answer 16

Hypercalcaemia

Question 17

Amiodarone important blood test

Answer 17

Thyroid function - causes hypo and hyper

Monitor TFTs at baseline and 6-monthly

Question 18

Worst side effect of donepezil/rivastigmine/galantamine

Answer 18

Heart block - avoid verapamil/diltiazem

Question 19

Antibiotic causing QT prolongation

Answer 19

erythromycin

Question 20

High QRisk and DM - drug to think about

Answer 20

Dapagliflozin

Question 21

Most effective stop smoking drug

Answer 21

Varenicline (not available)

Question 22

Restless leg Rx

Answer 22

Pramipexole (dopamine agonist)
Gabapentinoid

Question 23

Drug causes of amenorrhoea

Answer 23

Chlorpromazine
Metoclopramide/Domperidone
(dopamine antagonists induce hyperprolactinaemia)

Question 24

QT prolonging antibiotics

Answer 24

Macrolides - clari, erythro, azithro

Question 25

Hyoscine - diluent for syringe driver

Answer 25

WFI - precipitates with saline

Question 26

Frequency of lithium monitoring and what to monitor

Answer 26

q3M first year then q6M Renal, Thyroid, Calcium, Lithium

Question 27

SSRI and anti-retroviral interaction

Answer 27

Both can prolong QT

Question 28

Contraindication to testosterone therapy

Answer 28

Liver disease - predisposes to tumours

Question 29

Elderly patient on long-term oral steroids

Answer 29

Co-prescribe bisphosphonate and/or calcium/vit D for duration of treatment

Question 30

Methotrexate monitoring

Answer 30

FBC and LFT every 2 weeks until stable then every 2-3 months