Pharmacology Flashcards
1
Q
What determines duration of action of local anaesthetics
A
Duration of action is directly proportional to protein binding
2
Q
What is the protein binding of lidocaine
A
70%
3
Q
What is the protein binding of bupivicaine
A
95%
4
Q
What determines the onset speed of local anaesthetics
A
Onset speed is inversely proportional to the pKa.
Bases are ionised below their pKa
5
Q
A
