pharmacology

Question 1

ear side effect of furosemide?

Answer 1

ototoxic- hearing loss

Question 2

best HRT for migraine prone women?

Answer 2

patches as less fluctating hormones which can cause migraines

Question 3

syx seretonin syndrome

Answer 3

confusion
agitation
myoclonus
sweating
fever
diarrhoea

Question 4

when to withhold statin?

Answer 4

with clarithromycin

Question 5

amiodarone and simvasstatin?

Answer 5

amiodarone increases SE of simvastatin

Question 6

SE methyphenidate

Answer 6

reduced growth
decreased appetite
alopecia
tachycardia
hypertension

Question 7

ciprofloxacin increase risk of?

Answer 7

tenon rupture eg achilles tenon
/tendonitis

Question 8

clarithromycin and cardiac risk?

Answer 8

increase risk of cardiac events EG MI due to rupture existing plaques

Question 9

how to wean off B blockers?

Answer 9

gadually over 2 weeks as sudden stops can cause rebound MIs

Question 10

Jarish- Herxheimer reaction
syx

Answer 10

eg common after starting treatment for syshphillis -its breakdown of bacterial cell wall by abx
syx
fever, chills, tachycardia, myalgia

Question 11

SE lithium?

Answer 11

hypernatraemia
confusion
tremors
vomiting

Question 12

harm of longterm nitrofurantoin?

Answer 12

pulmonary fibrosis

Question 13

anticoagulant of choice in pregnancy

Answer 13

heparin

Question 14

antidepressant with worst discontinuation side effects?

least likely to cause discontinuation?

Answer 14

venlafaxine
shortest half life and proxetine

fluoxetine

Question 15

SE carbamazepine?

Answer 15

leucopenia
agranulocytosis
thrombocytopenia

Question 16

drugs prolong QT

Answer 16

citalopram
clarithromycin

Question 17

mirtazapine SEs

Answer 17

15 mg starting dose
more sleepy
higher doses less sleepy

Question 18

breastfeeding and contraception

Answer 18

PRE 6 WEEKS do not want combined OCP as reduces breast milk production

Question 19

yellow fever contraindication

Answer 19

anaphylactic egg allergy

Question 20

emergency contraceptive if had bariatric surgery

Answer 20

copper intrauterine device

Question 21

antidepresssant to avoid with tamoxifen

Answer 21

fluoxetine reeduces efficacy

Question 22

SE colchichine

Answer 22

D+V

Question 23

thiazide diretic eg
indapamide
affect Na?

Answer 23

hyponatraemia

Question 24

raynauds phenomenon
med which
- causes
- treats

Answer 24

• B blocker cauases
• nifedipine CA channel blocker helps treat = dilates vessels

Question 25

best benzodiazapine to swap to reduce withdrawal from loraz?

Answer 25

diazepam

Question 26

cause drug induced psoriasis?

Answer 26

B blockers commonly

Question 27

risk with SGLT2 (eg dapagliflozin)

Answer 27

euglycaemic DKA can occur when dehydrated
- DKA syx, ketones but normal BM

Question 28

common SE metformin

Answer 28

abdo pain and diarrhoea

Question 29

order to treat folate and B12 deficiency

Answer 29

1) b12 first to avoid worsening neurological symptoms and precipitating subacute combined degeneration of cord

Question 30

drugs to avoid with methotrexate ?

Answer 30

Trimethoprim and co-trimoxazole
risk of bone marrow aplasia (both anti folate meds)

Question 31

Local anesthetic toxicity can be treated with

Answer 31

IV 20% lipid emulsion

Question 32

Visual changes secondary to drugs
blue vision:
yellow-green vision:]

Answer 32

Viagra (‘the blue pill’)
digoxin