HAEM

Question 1

ACUTE LYMPHOBLASTIC LUEKAEMIA
classic cells?

Answer 1

ALL cancer / aka most common in children
blast cells on blood film and bone marrow

Question 2

acute myeloid leukaemia

Answer 2

commonest leukaemia adults
blast cells + auer rods
anaemia, infection and bleeding

Question 3

CML chronic myeloid leukaemia
classic blood result?
chromosome present?
tx

Answer 3

WBC X10 normal eg 100
massive splenomegaly
philadelphia
tx = imatinib

Question 4

myelofibrosis
classic red cells?

Answer 4

tear drop red cell
myleocyrosis myley cyrus cry
spleno+hepatomegaly

Question 5

hodgkin vs non hodgkin

staging criteria

Answer 5

hodgkin = reed stern berg, more B symptoms
non hodgkin = no reed cells

ann arbor criteria

Question 6

CHOP tx for lymphoma

Answer 6

Cycolophosphamide
Hydroxydaunorubicin, Vincristine (oncovin)) and prednisolone

Question 7

cooleys anaemia
aka ?
signs?

Answer 7

B thallasaemia
presents with anaemia and childhood infections
signs = hepatosplenomegaly + unusually shaped facial bones

Question 8

sideroblastic anaemia
common cause

Answer 8

lead. poisioning

Question 9

ftt in B thallaseamia anaemic children - treatment

Answer 9

1) iron chelation wtih desferroxime
2) pituatory sensative to iron so give somatottropin to help growth hormone

Question 10

DIC dissemination intravascular coagulation classic cells ?

Answer 10

schistocytes due to microangiopathic haemolytic anaemia
↓ platelets
↓ fibrinogen
↑ PT & APTT

Question 11

most common cause of thrombophilia
: second most common cause

Answer 11

factor V Leiden (activated protein C resistance):
prothrombin gene mutation