Pharmacology Flashcards
TOPIRAMATE
Close angle glaucoma
Some cases can cause chordal effusions due to rotation of the ciliary body
TOPIRAMATE TX
👉🏽Partial seizures and
👉🏽severe tonic clonic (grand mal ) seizures
👉🏽migraine headaches
👉🏽also available under a different brand name to treat obesity
TOPIRAMATE
Mechanism of action
Blocks voltage - dependent sodium channel as well as AMPA and glutamate Rc.
Is a weak carbonic anhydride inhibitor
TOPIRAMATE and ZONISAMIDE increase the risk of renal stone formation.
ZONISAMIDE
Is a sulfa anticonvulsivant that blocks sodium and calcium channels
NPC1L1
NPC1L1 (Nieman Pick C1 like peptide)
Expressed at the gut lumen (apical) and the hepatobiliary ( canalicular ) interface in the intestinal epithelial cells.
This structure facilitates the internalization of free cholesterol into the enterocyte in conjunction with the adaptor protein 2 (AP2) complex.
EZETIMIBE
Inh NPC1L1 and decreases the delivery of intestinal cholesterol to the liver and reduces hepatic cholesterol stores resulting in increase in clearance of cholesterol from the blood
Also significantly lowers LDL level and is often combines with statins (HMG -CoA REDUCTASE INH) to achieve LDL TARGET.
EZETIMIBE
Adverse effects
Upper respiratory tract infections
Sinusitis
Has no clear effect on mortality
NPC1L1 also found in the upper respiratory tract
Bezlotoxumab
IgG monoclonal Ab
IgG monoclonal Ab against C.Diff toxin
Only agent used to prevent C. Diff infection in high risk patients (receiving antibiotics
First line Tx of C.Diff
Vancomycin and Fidaxomicin
Benzathine
Siphilis
Leptospirosis
Neisseria 👉🏽 meningitis
👉🏽Gonorrhea
Virus and group strep
Step pyogenes
HCTZ
Diuretic /thiazide
HCTZ
Diuretic /thiazide
Loop Diuretic
Furosemide
When ZOLENDRONATE is indicated
Is parentally administered bisphosphonate that is indicated in patients who are intolerant to oral therapy.
Or in whom orally administered are inappropriate such as those with Celiac disease, achalasia, or inflammatory bowel disease.
