Pharmacology Flashcards

1
Q

Pharmacokinetics=

A
  • What the body does to the drug
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2
Q

Drug

A

chemical substance of known structure which once administered produces a biological effect.

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3
Q

Medicine

A

usually one or more drug which is administered to produce therapeutic effect.

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4
Q

Therapeutics=

A
  • Use of drugs to diagnose, prevent and treat illness.
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5
Q

Formulations=

A

how a drug is packaged.

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6
Q

Excipient

A

substances formulated alongside drug.

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7
Q

Drugs usually have three different types of name. What are these?

A
  • Chemical name
  • Generic name
  • Proprietary name
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8
Q

Pharmacodynamics=

A

What drug does to body

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9
Q

Ligand=

A
  • Molecule that binds to the receptor
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10
Q

Receptor=

A

Molecular target for drug

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11
Q

Agonist=

A

Molecule that activates receptor

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12
Q

Antagonist=

A

Blocks/ reduces agonist mediated response

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13
Q

Exogenous Vs endogenous=

A

outside body vs inside body

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14
Q

What would an ideal drug do?

A
  • Produce pharmacological effect
  • Acceptable side effects
  • Reach target at right concentration at right time
  • Remain at sight of action for sufficient time
  • Be rapidly and completely removed from body
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15
Q

What are key aspects of drug binding?

A

Steric interaction & lock and key

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16
Q

What properties effect drug binding?

A

physio chemical & steric properties

17
Q

Affinity=

A

How well a ligand binds got a receptor

18
Q

Targets for drug interaction:

A

Receptor, ion channels, carrier molecules, enzymes (RICE)

19
Q

Families off drugs that interact with enzymes:

A
  • enzyme inhibitators
  • false substrates
  • prodrugs
20
Q

What is drug specificity?

A

No drugs act with complete specificity, non-specific interactions are possible. A drug may preferentially bind to its target but be promiscuous (act with multiple targets and produce pharmacological effects- side effects)

21
Q

What does pharmacokinetics involve?

A
  • Absorption
  • Distribution
  • Metabolism
  • Excretion
22
Q

Describe the process known as first pass metabolism.

A
  • Metabolism a drug undergoes before reaching systemic circulation. After oral administration drugs are absorbed from gastrointestinal tract and transported via portal vein to liver before entering systemic circulation.
23
Q

List four organs of the body where first pass metabolism takes place.

A
  • Liver
  • Lung
  • Intestinal wall
  • Intestinal lumen
24
Q

Bioavailibilty=

A
  • Proportion of active drug that reaches systemic circulation and is free to bind to its target. It is affected by route of administration.
25
Q
A