Pharmacology

Question 1

Acetazolamide MoA?

Answer 1

Carbonic anhydrase inhibitor

Reduces hydrogen ion secretion in the renal tubule which causes more sodium, potassium, bicarbonate and water to be excreted from the kidney

Main SE: Acute interstitial nephritis

Question 2

Sildenafil MoA?

Answer 2

Phosphodiesterase V Inhibitor

Inhibits breakdown of cyclic guanosine monophosphate in the pulmonary circulation

Question 3

Hyoscine MoA?

Answer 3

Anticholinergic drug

High affinity for muscarinic receptors located in the smooth muscles of the GI tract

Question 4

Bisphosphonate MoA?

Answer 4

Inhibits osteoclastic activity

Thereby increasing bone mass

Question 5

Rituximab MoA?

Answer 5

Acts against CD20 surface molecule on B cells

Question 6

Lidocaine MoA?

Answer 6

Prolongs inactivation of voltage gated sodium channels which prevents action potentials firing

Question 7

Fexofenidine MoA?

Answer 7

Histamine 1 antagonist

Question 8

Sulfasalazine MoA?

Answer 8

Inhibits leukotreines

Question 9

Ondansetron MoA?

Answer 9

Selective serotonin 5-HT3 receptor antagonist

Question 10

Ezetimibe MoA?

Answer 10

Inhibits dietary cholesterol absorption in the intestine by blocking NPC1L1

Question 11

SSRI MoA?

Answer 11

Selective serotonin reuptake inhibitor which specifically increases serotonin by blocking its reuptake from the synaptic cleft

Question 12

Ibuprofen MoA?

Answer 12

Reduced prostaglandin synthesis through non-selective inhibition of COX-1 and COX-2 enzymes

Question 13

Infliximab MoA?

Answer 13

Monoclonal antibody

Binds to TNF-alpha with high affinity

Question 14

Adenosine MoA?

Answer 14

A1 adenosine-receptor agonist

Question 15

Prostaglandin MoA?

Answer 15

Act on the EP4 receptor present in the smooth muscle of the ductus, which is coupled to the Gs G-protein-coupled receptor

Question 16

Adalimumab MoA?

Answer 16

TNF alpha inhibitor

Question 17

What is nitric oxide derived from?

Answer 17

L-arginine

Question 18

Sodium Valproate MoA?

Answer 18

Reduction in catabolism of GABA

Question 19

Tocolizumab MoA?

Answer 19

Monoclonal antibody which acts by inhibition of interleukin 6 receptors (IL6)

Question 20

NAC MoA?

Answer 20

Directly increases glutathione production in the liver by producing cysteine

Question 21

Treatment of Meningitis?

Answer 21

Amoxicillin - covers listeria
Cefotaxime