Pharmacology

Question 1

What does a virus attach to on the surface of the host cell in order to enter the cell?

Answer 1

Receptor

Question 2

Once the RNA virus enters the cell, what does it require a good supply of for genomic replication?

Answer 2

ribonucleoside triphosphates

Question 3

Once the DNA virus enters the cell, what does it require a good supply of for genomic replication?

Answer 3

deoxyribonucleoside triphosphates

Question 4

Which enzyme helps catalyze the formation of deoxyribonucleoside triphosphates?

Answer 4

Thymidine kinase

Question 5

This drug has selective inhibition of thymidine kinase.

Answer 5

Acyclovir (ACV)

Question 6

This drug, when phosphorylated, accumulates in almost all cells in the body so its toxicity is a serious clinical issue.

Answer 6

Zidovudine (AZT)

Question 7

This drug is given to pt’s with chronic HBV infections with active virus replication.

Answer 7

lamivudine (3TC)

Question 8

3TC triphosphate, adefovir, and entecavir all inhibit which enzyme, which is important for HBV infections?

Answer 8

Reverse transcriptase

Question 9

This broad spectrum antiviral is used for RSV infections and hep C infections.

Answer 9

Ribavirin

Question 10

Ribavirin is used with what other drug to treat HCV?

Answer 10

interferon

Question 11

How does the Ab in an immunization block the action of the virus once the Ab attaches to the viral envelope proteins?

Answer 11

it blocks the attachment and penetration of the virions into the host cells and increase the virion clearance.

Question 12

True or False: interferon directly targets viral gene products to inhibit replication.

Answer 12

False. it uses the innate immune response to kill viruses.

Question 13

How does the binding of the interferon to the PKR cause the halt in virus production?

Answer 13

it turns off host cell protein synthesis, which turns of viral production.