PHARMACOLOGY Flashcards
what is orlistat?
a synthetic derivative of lipstatin
what is orlistats mechanism of action?
it inhibits pancreatic lipase which reduces the breakdown and absorption of fat in the diet
what drug class is liraglutide?
GLP1R agonist
what type of drug is bupropion?
aminoketone druga noradrenalinę/dopamine reuptake inhibitor
antagonist of nicotinic ACh receptors
an antidepressant
has some clinical effectiveness with obesity where over-eating owing to psychological issues is a major identified course
what drug class is lorcaserin?
benzazepine drug
a serotonin 5-HT2C receptor agonist
how does lorcaserin work?
increases proopiomelanocortin production in the hypothalamus to increase feelings of satiety but may also reduce brain levels of neuropeptide Y to decrease feelings of hunger
what drug class is phentermine?
a phenylbutylamine drug
how does phentermine work?
its an agonist at trace amine associated receptors (TAAR1) where it promotes noradrenaline release. its therefore a psychostimulant and an appetite suppressant
what are the indications of orlistat?
to help those with a BMI over 30 lose weight
what are indications of liraglutide
to improve glycemic control in type 2 diabetes and to reduce the risk of major adverse cardiovascular events
what are indications of bupropion?
major depression
stopping smoking
weight management
what are the indications of lorcaserin?
weight management
what are the indications of phentermine?
weight reduction
