Pharmacological Treatment of Thyroid Disorders

Question 1

What is Liothyronine?

Answer 1

Synthetic sodium salt of iodothyronine.

Question 2

What are drugs used for hypothyroidism?

Answer 2

Liothyronine, Liotrix, Levothyroxine.

Question 3

What is the action of liothyronine?

Answer 3

Orally (90% absorbed from GI), rapid onset of action.

Question 4

What is the duration of liothyronine?

Answer 4

Peak effect & duration of action are relatively short.

Question 5

What is Liotrix?

Answer 5

A mixture of T4 & T3 in the ratio of 4:1

Question 6

What is the action of liotrix?

Answer 6

Orally active.

Question 7

What is levothyroxine?

Answer 7

Synthetic sodium salt of thyroxine, has long half-life & better tolerated than liothyronine & liotrix.

Question 8

What is the action of levothyroxine?

Answer 8

Orally effective (less absorbed than liothyronine) & has slower onset of action when given orally.

Question 9

What are the therapeutic uses for the thyroid hormone drugs?

Answer 9

1- hashimoto disease.
2- myxedema.
3- simple goiter.
4- Replacement therapy 
5- TSH- dependent carcinomas

Question 10

What are the adverse effect of hypothyroidism drugs?

Answer 10

Same as hyperthyroidism (tachycardia, palpitations, iatrogenic hyperthyoidism, anxiety, angina, hear intolerance).