Glucocorticoid inhibitors Flashcards
1
Q
What are the glucocorticoid inhibitors?
A
Aminoglutethimide, Ketoconazole, Metyrapone, Mifepristone.
2
Q
What is the aminoglutethimide MOA?
A
Inhibits the rate limiting step in the biosyhthesis of most steroid hormone.
3
Q
What is the indication of the aminoglutethimide?
A
Treat breast cancer.
4
Q
What is ketoconazole MOA?
A
Inhibits many enzymes in steroid biosynthesis pathway.
5
Q
What is metyrapone MOA?
A
Inhibits 11B- HSD (Convert deoxycortisol to cortisol).
6
Q
What is the diagnosis of metyrapone?
A
Metyrapone stimulation test.
7
Q
What is mifepristione MOA?
A
Blocks (inhibits) glucocorticoid receptors (primarly, introduced as progestin receptor blocker.
8
Q
What can mifepristone used for?
A
Treating cushing syndrome.
