Glucocorticosteroids Flashcards
How is prednisolone synthesized?
Adding double bond between C1 & C2.
What is the action of prednisolone?
Intermediate acting steroid (12-36hrs), has less salt retaining (mineralocorticoid) activity.
How is fludrocortidone synthesized?
Adding a fluro group to 9 position.
What isv the action of fludrocortisone (9- flurocortisol)?
Intermediate acting steroid (12-36hrs), has increased salt (mineralocorticoid) activity.
How is triamcinolone synthesized?
Adding OH to 16 position.
What is the action of triamcinolone?
Intermediate acting steroid (13-36hrs), no salt regaining (mineralocorticoid) activity.
How is dexamethasone synthesized?
Adding methyl group to 16 position.
What is the action of dexamethasone?
Long- acting steroid (36-54hrs), no salt retaining (mineralocorticoid) activity.
Where is dexamethasone used?
Dexamethasone suppression test.
What is the action of betamethasone?
Long- acting steroid (36-54hrs), has no salt retaining (mineralocorticoid) activity.
What is the indication of beclomethasone?
Inhaled glucocorticoid used to treat asthma.
What is side effect of beclomethasone?
Oropharyngeal candidasis.
