Pharmacological Rx

Question 1

True or false

All non-opioid medications can be given orally. ?

Answer 1

True

Question 2

True or false

All of Non-opioid pain management drugs are also available as suppositories for rectal administration

and parenteral form for intravenous administration.

Answer 2

True

Question 3

MOA of Opioid analgesics ?

Answer 3

bind to and activate specific receptor sites in the CNS & PNS.

Once these receptor sites are activated
= pain signal transmission is blocked,
–> producing
analgesia.

Question 4

Name four

µ (mu) agonist opioids used in Pain management

Answer 4

Morphine,
fentanyl,
hydromorphone, oxycodone

bind primarily to the µ opioid receptors to produce both wanted (analgesia) and unwanted (adverse) effects.

Question 5

Most Common Adverse Effects of Opioids ?

Answer 5

• Nausea
• Vomiting
• Pruritus
• Constipation
• Sedation

Question 6

What should be co-prescribed with Opioids ?

and why ?

Answer 6

stool softener + laxative

to prevent constipation

Question 7

What side effects of opioids are dose related ?

Answer 7

Nausea
Vomiting
Pruritus
Sedation

Question 8

Which side effect of opioids is not dose - related ?

Answer 8

constipation

Question 9

how do you reduce dose related opioid side effects ?

Answer 9

Reduce dose of opiods.

Question 10

Most dangerous side effect of opioids ?

Answer 10

respiratory depression

Thus inspect respiratory status during - particularly in first 24 hours.

Question 11

sign of respiratory obstruction ?

Answer 11

 Snoring

must be attended to promptly

Question 12

What to do in respiratory depression ?

Answer 12

Give
µ receptor antagonist
= naloxone

will reverse the sedating and respiratory depressant effects of opioids.