Pharmacokinetics and Pharmacodynamics

Question 1

ABSORPTION (process)

Answer 1

MOVEMENT from APPLICATION SITE to EXTRA-CELLULAR FLUID

Question 2

ACTIVE TRANSPORT

Answer 2

MECHANISM REQUIRING ENERGY

Question 3

AFFINITY

Answer 3

TENDENCY TO COMBINE (with receptor)

Question 4

AGONIST

Answer 4

SUBSTANCE
BINDS with SPECIFIC RECEPTOR
CAUSES PL RESPONSE

Question 5

ALBUMIN

Answer 5

MOJOR PROTEIN in human blood

Question 6

ANTAGONISTS

Answer 6

BLOCKING SUBSTANCES of PLR and ACTION of other substances

Question 7

BINDING CAPACITY

Answer 7

the DEGREE to which a substance is bound to TISSUE or PLASMA

Question 8

BIOTRANSFORMATION

Answer 8

PROCESS of the body also called METABOLISM

changing a substance into a different form.. active or inactive

Question 9

BLOOD BRAIN BARRIER

Answer 9

SELECTIVE ENTRY CNS PROTECTIVE BOUNDARY MECHANISM from PNS

Question 10

DISTRIBUTION

Answer 10

PROCESS of TRANSPORTATION

site of absorption—–>site of action

Question 11

DOSE

Answer 11

MEASURED PORTION taken ONCE

Question 12

DOSAGE

Answer 12

AMOUNT for a GIVEN CONDITION or case

Question 13

EFFICACY

Answer 13

the POWER to PRODUCE therapeutic EFFECT

Question 14

ELIMINATION (process)

Answer 14

SUBSTANCE REMOVAL

Question 15

EXCRETION (process)

Answer 15

WASTE ELIMINATION

Question 16

GLOBULIN

Answer 16

ONE type of SIMPLE PROTEIN

Question 17

HALF LIFE

Answer 17

TIME for blood level to reach HALF of its administered level

Question 18

HOMOGLOBIN

Answer 18

IRON containing COMPOUND for TRANSPORTATION and DELIVERY

Question 19

LOADING DOSE

Answer 19

describes the INITIAL dose of AT LEAST the amount required for THERAPEUTIC EFFECTIVENESS

Question 20

MAINTENANCE DOSE

Answer 20

the DOSE necessary to MAINTAIN a CONSTANT THERAPEUTIC PLASMA LEVEL

Question 21

MECHANISM OF ACTION

Answer 21

the BIOCHEMICAL and PHYSIOLOGICAL EVENTS that occur WHEN SUBSTANCE REACHES THE TARGET TISSUE

Question 22

METABOLISM

Answer 22

the SUM of ALL PHYSICAL and CHEMICAL CHANGES in THE BODY

Question 23

MINIMUM EFFECTIVE CONCENTRATION

Answer 23

MINIMUM AMOUNT needed in BLOOD for DESIRED THERAPEUTIC EFFECT to occur

Question 24

ONSET OF ACTION

Answer 24

TIME between ADMINISTRATION and FIRST SIGN OF ONSET

chem/phys properties & ROA are influencers

Question 25

PASSIVE TRANSPORT

Answer 25

MECHANISM of TRASPORT - DOESNT require energy to move a substance

Question 26

pH

Answer 26

EXPRESSION of ACIDITY or ALKALINITY | logarithm of hydrogen ion concentration/1

Question 27

PHARMACODYNAMICS

Answer 27

the STUDY of ACTION | of substances on the body

Question 28

PHARMACOKINETICS

Answer 28

the STUDY of MOVEMENT of medications from IN to OUT

Question 29

SOLUBILITY

Answer 29

the TENDENCY it has to DISSOLVE

Question 30

THERAPEUTIC INDEX

Answer 30

is a SAFETY PROFILE determined by calculating the DIFFERENCE between THERAPEUTIC THRESHOLD and TOXIC LEVEL

Question 31

THERAPEUTIC THRESHOLD

Answer 31

same as MINIMUM EFFECTIVE CONCENTRATION

Question 32

TOXIC LEVEL

Answer 32

PLASMA LEVEL at which SEVERE ADVERSE REACTIONS or expected or likely