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Pharmacology > Pharmacokinetics and Pharmacodynamics > Flashcards

Pharmacokinetics and Pharmacodynamics Flashcards

1
Q

ABSORPTION (process)

A

MOVEMENT from APPLICATION SITE to EXTRA-CELLULAR FLUID

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2
Q

ACTIVE TRANSPORT

A

MECHANISM REQUIRING ENERGY

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3
Q

AFFINITY

A

TENDENCY TO COMBINE (with receptor)

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4
Q

AGONIST

A

SUBSTANCE
BINDS with SPECIFIC RECEPTOR
CAUSES PL RESPONSE

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5
Q

ALBUMIN

A

MOJOR PROTEIN in human blood

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6
Q

ANTAGONISTS

A

BLOCKING SUBSTANCES of PLR and ACTION of other substances

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7
Q

BINDING CAPACITY

A

the DEGREE to which a substance is bound to TISSUE or PLASMA

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8
Q

BIOTRANSFORMATION

A

PROCESS of the body also called METABOLISM

changing a substance into a different form.. active or inactive

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9
Q

BLOOD BRAIN BARRIER

A

SELECTIVE ENTRY CNS PROTECTIVE BOUNDARY MECHANISM from PNS

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10
Q

DISTRIBUTION

A

PROCESS of TRANSPORTATION

site of absorption—–>site of action

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11
Q

DOSE

A

MEASURED PORTION taken ONCE

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12
Q

DOSAGE

A

AMOUNT for a GIVEN CONDITION or case

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13
Q

EFFICACY

A

the POWER to PRODUCE therapeutic EFFECT

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14
Q

ELIMINATION (process)

A

SUBSTANCE REMOVAL

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15
Q

EXCRETION (process)

A

WASTE ELIMINATION

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16
Q

GLOBULIN

A

ONE type of SIMPLE PROTEIN

17
Q

HALF LIFE

A

TIME for blood level to reach HALF of its administered level

18
Q

HOMOGLOBIN

A

IRON containing COMPOUND for TRANSPORTATION and DELIVERY

19
Q

LOADING DOSE

A

describes the INITIAL dose of AT LEAST the amount required for THERAPEUTIC EFFECTIVENESS

20
Q

MAINTENANCE DOSE

A

the DOSE necessary to MAINTAIN a CONSTANT THERAPEUTIC PLASMA LEVEL

21
Q

MECHANISM OF ACTION

A

the BIOCHEMICAL and PHYSIOLOGICAL EVENTS that occur WHEN SUBSTANCE REACHES THE TARGET TISSUE

22
Q

METABOLISM

A

the SUM of ALL PHYSICAL and CHEMICAL CHANGES in THE BODY

23
Q

MINIMUM EFFECTIVE CONCENTRATION

A

MINIMUM AMOUNT needed in BLOOD for DESIRED THERAPEUTIC EFFECT to occur

24
Q

ONSET OF ACTION

A

TIME between ADMINISTRATION and FIRST SIGN OF ONSET

chem/phys properties & ROA are influencers

25
Q

PASSIVE TRANSPORT

A

MECHANISM of TRASPORT - DOESNT require energy to move a substance

26
Q

pH

A

EXPRESSION of ACIDITY or ALKALINITY

logarithm of hydrogen ion concentration/1

27
Q

PHARMACODYNAMICS

A

the STUDY of ACTION

of substances on the body

28
Q

PHARMACOKINETICS

A

the STUDY of MOVEMENT of medications

from IN to OUT

29
Q

SOLUBILITY

A

the TENDENCY it has to DISSOLVE

30
Q

THERAPEUTIC INDEX

A

is a SAFETY PROFILE
determined by calculating

the DIFFERENCE

between THERAPEUTIC THRESHOLD
and
TOXIC LEVEL

31
Q

THERAPEUTIC THRESHOLD

A

same as MINIMUM EFFECTIVE CONCENTRATION

32
Q

TOXIC LEVEL

A

PLASMA LEVEL at which SEVERE ADVERSE REACTIONS or expected or likely

Pharmacology (4 decks)

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