Pharmacokinetics- Absorption Flashcards
1
Q
What are the routes of Administration?
A
Oral or rectal -> Urine/Faeces
Percutaneous
Intravenous
Intramuscular
Intrathecal
Inhalation -> expired air
2
Q
What are the three factors affecting absorption?
A
Physiological factors
Drug factors
Disease factors
3
Q
What are physiological factors affecting absorption?
A
Enzymes pH Bacteria Blood flow Surface area Transit time Active/facilitated transport
4
Q
What are the drug factors affecting absorption?
A
Formulation Molecular size Particle size Physical structure Chemical structure Lipid/water solubility Ionisation Drug/food interaction
5
Q
What are the disease factors affecting absorption?
Also what three surgical procedures affect absorption?
A
Coeliacs disease Crohn’s disease Diarrhoea Ulcerative colitis Atonic GIT
Ileostomy
Gastrectomy
Small bowel reduction
6
Q
What is the pathway of enterohepatic recirculation?
A
Liver -> conjugation-> Drug glucoronide -> intestine -> bacteria -> drug metabolites -> absorption
