Pharmacokinetic principles Flashcards
What are the two principles of pharmacology?
Pharmacokinetics and Pharmacodynamics
What intravenous routes influences the drug doses for effects on plasma concentrations?
Bolus
Intermittent infusion
Continuous infusion
What is Apparent volume of distribution (vD)
The volume of plasma in which the total amount of drug in the body would be required to be dissolved to reflect drug concentration attained in the plasma
How do you calculate vD?
vD = Dose / plasma concentration
What is elimination rate constant (K) ?
The proportion of plasma concentration eliminated per unit time
What is clearance?
The proportion of vD that is cleared of drug per unit of time
Cl = vD times K
What is bioavailability?
The fraction of drug that reaches systemic circulation.
What is the bioavailability when a drug is administered intravenously?
F = 1 (100%h
What is the calculation for absolutely bioavailability?
[AUC]Oral / [AUC] IV
What is the calculation for Relative Bioavailability?
[AUC]FormA / [AUC]FormB
What are the 4 elements of pharmacokinetics?
Absorption
Distribution
Metabolism
Excretion
