Pharmacokinetics Flashcards
1
Q
Dosing in Obesity: Total Body Weight
A
Vancomycin, Daptomycin
2
Q
Dosing in Obesity: Adjusted Body Weight
A
Aminoglycosides, Colistin, Voriconazole, (Acyclovir), (TMP/SMX)
3
Q
Dosing in Obesity: Ideal Body Weight
A
Flucytosine, (Acyclovir), (TMP/SMX)
4
Q
Carbapenem drug interactions
A
Reduced concentration of VPA, may decrease absorption or enterohepatic recalculation or disrupt metabolism
5
Q
Voriconazole genetic variability
A
Due to CYP 2C19; Asians typically have lower 2C19
6
Q
Flucytosine TDM target
A
Trough: 20-40 Peak:<100
7
Q
Colistin base to CMS
A
30mg CBA = 80mg CMS
8
Q
Polymyxin B dose in IU
A
10,000 IU = 1mg
9
Q
Polymyxin B loading dose
A
20,000-25,000 IU/kg = 2-2.5mg/kg
