Principles Of ID Flashcards
1
Q
Activity of Avibactam vs blmase classes
A
Avibactam has activity against Ambler class A and C carbapenemases, lim- ited activity against class D OXA β-lactamases, and no activity against metallo-β-lactamases.
2
Q
GAIN Act Key Characteristics
A
3
Q
Mechanism of ertapenem for KPC infections
A
Ertapenem has high af nity for KPC-type carbapenemases. Combination of ertapenem as a sacri- cial substrate allows the anti-pseudomonal carbapenem to function.
4
Q
Changes to Vd in critically ill patients and drug class most effected
A
In critically ill patients with capillary leak, the Vd increases, which decreases the serum concentration of hydrophilic drugs.
