Pharmacokinetics

Question 1

What the body does tot he drug

Answer 1

Pharmacokinetics

Question 2

Movement of a drug from the site of administration into the blood

Answer 2

Absorption

Question 3

Once int he blood, the drug moves to various parts of the body

Answer 3

Distribution

Question 4

The drug is converted to a form that is more readily eliminated

Answer 4

Biotransofmation (metabolism)

Question 5

Metabolism or excretion of the drug from the body

Answer 5

Elimination

Question 6

When does it change from pharmacokinetics to pharmacodynamics

Answer 6

Once it gets to the site of action

Question 7

What is the most common type of route of administration

Answer 7

Oral

Question 8

Convenient route, but slower and less complete than parenteral forms

Answer 8

Oral administration

Question 9

What are orally administered drugs subject to

Answer 9

First pass effect

Question 10

Blood from the GI tract passes through the liver before entering other organs; during this, some or nearly all of the drug can be metabolized to an inactive or less active derivative; as a result some drugs are useless when given orally

Answer 10

First pass effect

Question 11

Parenteral

Answer 11

Goes around the GI tract

Question 12

What is a parenteral type of administration

Answer 12

IV

Question 13

Most common route of administration

Answer 13

Oral

Question 14

What is the safest route of administration

Answer 14

Oral

Question 15

What is the most economical route of administration

Answer 15

Oral

Question 16

Where is he major sire of absoprtion after oral administration

Answer 16

Small intestines

Question 17

What can absorption be affected by when taking it orally

Answer 17

Affected by stomach contents

Question 18

This route of administration is given under the tongue and offers the same feature as the buccal route

Answer 18

Sublingual

Question 19

This route is very fast and voids the 1st pass effect

Answer 19

Sublingual

Question 20

Why is sublingual absorption so fast?

Answer 20

Vasculature of the mouth

Question 21

Which is faster route of administration, subcuataneous or intramuscular

Answer 21

IM, there is more vasculature in muscle than in fat

Question 22

Absoprtion from an ______ sire is often faster and mroe complete than with oral

Answer 22

Intramuscular

Question 23

What is an advantage to IM route of administration other than fast absorption

Answer 23

Large volume may be given

Question 24

This allows large volume doses but is slower

Answer 24

Subcutaneous

Question 25

Example of subcutaneous drug

Answer 25

Insulin

Question 26

What type of administration requires NOT absorption

Answer 26

Intravenous

Question 27

What is the fastest route of administration

Answer 27

Inhalation, delivers closest to the target tissue. Provides the most rapid absoprtion because of the large alveolar surface area available

Question 28

What’s the difference between topics and transdermal

Answer 28

Topical is applied to skin for a local effect

Transdermal is applied to the skin for a systemic effect.

Question 29

Is albuterol topical or inhalation

Answer 29

Topical

Question 30

What are the three types of drug movement within the body

Answer 30

Passive diffusion
Facilitated diffusion
Active transport

Question 31

Driven by concentration gradient across a membrane and has no carrier, therefore it is not saturable

Answer 31

Passive diffusion

Question 32

Drive by a concretation gradient, involves specific carrier proteins, is saturable, no energy required

Answer 32

Facilitated diffusion

Question 33

Moves against a conceration gradient and involves specific carrier proteins. It is saturable and needs ATP

Answer 33

Active transport

Question 34

What questions to ask if you are trying to figure out what kind of transport the drug is using

Answer 34

• Does it need a carrier? If you increase the cxn and the movment increases every time, it does not require carriers and is therefore not saturable
• if increased cxn where movment stops, it is saturable, rule out passive
• does it need energy? If inhibit ATP and the drug stopped moving, it needed ATP and therefore would be active transport