Pharmacokinetics Flashcards
1
Q
Volume of distribution
A
Vd = D/C
2
Q
Half life
A
t1/2 = 0.7*(Vd/Cl)
3
Q
Infusion Rate
A
k0 = Cl*Css
4
Q
Loading Dose
A
LD = (Vd*Cp)/f
5
Q
Maintenance Dose
A
MD = (ClCssdose interval)/f
disregard dose interval and f if it is continuous
6
Q
Rate of elimination
A
GFR + active secretion + reabsorption
7
Q
Clearance
A
Cl = f*GFR
8
Q
Time to SS
A
4 or 5 half lives
9
Q
Zero order
A
constant amt eliminated per unit time
Ex: phenytoin, ethanol, salicylate
10
Q
First order
A
constant fraction eliminated per unit time
Ex: most drugs
11
Q
Phase I
A
modification of drug via oxidation, reduction, or hydrolysis
12
Q
Phase II
A
conjugation with endogenous compounds via transferase
Ex: glucuronidation, acetylation, GSH conjugation
