Immunopharm Flashcards
1
Q
Cyclosporine
- MOA
- use
- SE
A
- bind cyclophilin–>decrease calcineurin–>decrease activation of T cell transcription factors–>decrease IL-2 and IL-3 and interferon gamma
- DOC for organ andtissue transplant (+/- mycophenolate, steroids, and cytotoxic drugs)
- nephrotoxic, gingival overgrowth
2
Q
Tacrolimus
- MOA
- use
- SE
A
- bind FK binding protein–>decrease calcineurin–> decrease activation of T cell transcription factors–> decrease IL-2 and IL-3 and interferon gamma
- alt to cyclosporine in renal and liver transplant
- nephrotoxic
3
Q
Mycophenolate
A
- inhibit de novo synthesis of purines
- permits reduction in dose of cyclosporine
4
Q
Azithioprine
A
- immunosuppressant converts to 6-MP
5
Q
Anti-D Ig
A
IgG antibodies to red cell D antigen
- give to Rh- moms who give birth to Rh+ babies
6
Q
Cytokines
- interferon alpha
- interferon beta
- interferon gamma
A
interferon alpha, beta and gamma
alpha: hep B and hep C, leukemia, and melanoma
beta: MS
gamma: chronic granulomatous disease–>increase TNF
7
Q
Abciximab
A
antiplatelet- antagonist of IIb/IIIa receptors
8
Q
Infliximab
A
RA and Crohns- binds TNF
9
Q
Trastuzumab
A
breast cancer- antag ERB-B2 (Her 2/neu)
10
Q
Dacliximab
A
Kidney transplant- block IL-2 receptor
11
Q
Muromonab
A
Kidney transplant- block allograft rejection
12
Q
Palivizumab
A
RSV- block RSV protein
13
Q
Rituximab
A
Non-Hodgkin lymphoma- binds surface protein
