Pharmacokinetics Flashcards
pharmacokinetcs
how the body interacts with a drug
pharmacodynamics
effect of the drug on the body
total body clearance
volume of blood cleared of patent drug per unit time
bioavailability
fraction of administered dose that reaches the plasma
compartment modesl
one compartment - spreads evenly through body
two compartment - vessel rich group first then distributed around rest of body
drug receptor types
ion channel cell surface transmembrane receptor
ligand regulated
g protein coupled
protein synthesis regulating
loading dose
initial higher dose at beginning of course of treatment before dropping to maintenance dose
useful for drugs that are eliminated from body slowly
constant rate infusion (CRI)
constant administration through IV drip
easier to keep within therapeutic range
intermittent dosing
spikes so more likely to over or under dose
affinity
tendency of a drug to bind to a receptor
efficacy
tendency of drug to activate a receptor once bound
agonist
response every time drug interacts with its target
partial agonist
activates receptor but not every time
antagonists
bind to receptor and block action
competitive - compete with agonists for binding site - higher concentration needed for same effect
non-competitive - binding at different receptor changing shape or block events by binding downstream - needs higher concentration but won’t reach same effect
irreversible - antagonist doesn’t detach from receptor (covalent bonds) - can’t be overcome by adding more agonist
inverse agonist
drug reduces activation of a receptor
