Pharmacokinetic applications Flashcards
1
Q
What do drugs which damage the kidney reduce
A
The eGFR
2
Q
What is tau
A
Dosage interval
3
Q
What are the three important measures when designing dosage regimens
A
1) Therapeutic window
2) Urgency of onset of effect (therefore may give a loading dose followed by a maintenance dose)
3) Elimination of half-life
4
Q
When is a loading dose given
A
To achieve a rapid rise to Css (ie in an emergency)
5
Q
What would you aim to do when you give a patient Gentamicin and why
A
Have a period of time where the concentration is sub therapeutic because gentamicin is toxic to the kidneys and causes deafness
6
Q
How do you measure the gentamicin in the blood
A
Measure the creatinine in the blood as it is equal to the creatinine clearance
