Introduction to pharmacokinetics

Question 1

What is plasma level profile of a drug given by

Answer 1

I.v infusion

Question 2

What is steady state

Answer 2

Administration rate=elimination rate

Question 3

What is the first pass effect

Answer 3

when concentration of a drug falls even before it reaches where its supposed to be

Question 4

What is zero-order process

Answer 4

Administration of drug at a constant rate

Question 5

What is Css

Answer 5

Steady-state concentration (Css) is defined as the time during which the concentration remains stable or consistent when the drug is given repeatedly or continuously (IV infusion).

Question 6

What should the maintenance dose be

Answer 6

Amount removed

Question 7

Once Css is achieved, what is input equal to

Answer 7

Output

Question 8

In single oral dosing, what is the shape of the overall plasma level/time curve influenced by

Answer 8

Rate of dissolution (if tablet)

Rate of absorption

Question 9

What data is important in pharmacokinetics

Answer 9

Absorption rate constant
Time to peak
Bioavailability

Question 10

What symbol is used for bioavailability

Answer 10

F

Question 11

What is bioavailability

Answer 11

The fraction absorbed

Question 12

Formula for bioavailability

Answer 12

AUC oral/AUC iv

Question 13

Approximately how many half lives does it take to achieve steady state

Answer 13

5