Pharmacogenomics

Question 1

genetic trait defined by the DNA sequences

Answer 1

genotype

Question 2

biologic or measurable expression of the genetic trait that’s dependent upon the level of % of the gene, the accuracy of the measurement method, and the influence of environmental factors

Answer 2

phenotype

Question 3

pharmacodynamics involve _____ and ______, while pharmacokinetics involve _____ and ______.

Answer 3

receptors; drug targets
enzymes; transporters

Question 4

pharmacodynamic = usually _______ the drug

Answer 4

substitute

Question 5

pharmacokinetic = _______ the drug or dose

Answer 5

adjust

Question 6

catalyzes the N-acetylation of aromatic amine and hydrazine drugs

Answer 6

N-acetyltransferase 2

Question 7

slow acetylators are predisposed to?

Answer 7

• peripheral neuropathy from isoniazid
• drug induced SLE from procainamide and hydralazine
• urinary bladder cancer from tobacco use

Question 8

rapid acetylators are predisposed to?

Answer 8

• myelosuppression from amonafide
• colorectal cancer from dietary carcinogens

Question 9

catalyzes the deactivation of anticancer and and antiinflammatory drugs

Answer 9

Thiopurine-S-Methyltransferase (TPMT)

Question 10

catalyzes the glucuronidation of bilirubin and xenobiotics

Answer 10

uridine diphosphate glucuronosyltransferase (UGT)

Question 11

important in the oxidation of a wide variety of drugs

Answer 11

CYP2D6

Question 12

catalyzes the oxidation of warfarin

Answer 12

CYP2C9

Question 13

mediate critical sympathetic responses in the cardiovascular, pulmonary, metabolic, and central nervous systems

Answer 13

beta adrenergic receptors