Pharmacodynamics

Question 1

what are the four targets of for drug action?

Answer 1

1. ) receptors
2. ) ion channels
3. ) enzymes
4. ) transporters

Question 2

What are the two types of dose response relationships?

Answer 2

Graded and Quantal

Question 3

What information can be gathered from graded and quantal repsonse curves? (2)

Answer 3

potency and selectivity

Question 4

Identify the type of dose response curve.

Answer 4

Graded

Question 5

Identify the type of dose response graph.

Answer 5

Quantal

Question 6

Dose response was collected from preclinical data and illustrated below. Which drug had the most efficacy?

Answer 6

Drug C; C produces the highest strove volume which make it more efficacious

Question 7

Which drug from the graph is the most potent?

Answer 7

Drug A

Question 8

If you were comparing three drugs to see which drug was the most potent beta 2 receptor agonist, which biomarker would you screen for?

Answer 8

ED50; the dose at which 50% of the maximal effect is produced

Question 9

What are some examples of reversible competitive antagoinsts?

Answer 9

naloxone, propranolol, flumazenil

Question 10

What are the two categories of hepatic reactions?

Answer 10

Phase I (nonsynthetic, preparatory) and phase 2 (synthetic, ex: glucoronidation, methylation, acetylation)