Antithrombotics

Question 1

what is the most common adverse event for anti-thrombotics

Answer 1

bleeding

Question 2

which drug is an ATP analogue and IV only drug?

Answer 2

cangrelor

Question 3

inhibitor of phosphodiesterase 3 and leads to increase in intraplatelet cAMP levels

Answer 3

cilostazol

Question 4

which other drug mentioned in class is PDE3 in the myocytes and was given to pts but people were killed faster?

Answer 4

milrinone

Question 5

blocks the platelet thrombin receptor

Answer 5

vorapaxar

Question 6

Which drug would be used to reverse heparin?

Answer 6

protamine sulfate

Question 7

which drugs are factor Xa specific?

Answer 7

low molecular weight heparins

Question 8

low molecular weight heparins

Answer 8

“parins” (enoxaparin, dalteparin, tinzaparin )

Question 9

which drugs both have black box warnings of spinal and epidural hematomas?

Answer 9

synthetic pentasaccharide (fondaparinmux) and Low molecular weight heparin (LMWH)

Question 10

List three direct thrombin inhibitors

Answer 10

bilvalirudin ( reversible DTI), argatroban (univalent DTI), dabigatran

Question 11

Warfarin interferes with the synthesis of vitamin K dependent clotting factors. Which factors are primarily affected?

Answer 11

II, VII, IX, X

Question 12

what is required to eliminate warfarin?

Answer 12

CYP2C9

Question 13

If a patient is taking warfarin what should the INR be between?

Answer 13

2-3

Question 14

which vitamin K is found in food?

Answer 14

K1 phytonadione

Question 15

which vitamin K is made by intestinal bacteria?

Answer 15

K2 menaquinone

Question 16

Factor Xa inhibitors

Answer 16

rivaroxaban, apixaban, edoxaban

Question 17

Factor IIa inhibitor

Answer 17

dabigatran

Question 18

which direct oral anticoagulant is available as a prodrug?

Answer 18

dabigatran

Question 19

which direct oral anticoagulant has CYP3A4 liver metabolism?

Answer 19

rivaroxaban