Pharmacodynamics

Question 1

Pharmacodynamics

Answer 1

The study of the biochemical and physiological effects of drugs on the body and their mechanism of action

Question 2

Receptors

Answer 2

Bind with the drug to produce a drug-receptor complex and and effect

Question 3

Pharmacodynamic Response

Answer 3

Describe the effect of the drug on the body.

Question 4

Quantal dose-response relationship

Answer 4

plots fraction of population that respond to give drug dose as function of dose.
Effectiveness, toxicity, and lethality

Question 5

Graded dose- response curve

Answer 5

Demonstrates the effect of a drug as function of its concentration.

Question 6

Efficacy

Answer 6

Maximal response produced by a drug

Question 7

Potency

Answer 7

The amount of drug needed to elicit a give response. the lower he dose required the more potent the drug.

Question 8

Slope of dose

Answer 8

Response curve -> steep slope ->small increase in dose produces large changes in response

Question 9

Active Receptor

Answer 9

Binds the drug

Question 10

Inactive receptor

Answer 10

unable to bind the drug

Question 11

Agonist

Answer 11

Binds receptors and activates

Question 12

Partial agonist

Answer 12

binds receptor at active site and produces only a partial response even when all the receptors are bound by the partial agonist.

Question 13

SERMS

Answer 13

Act as a partial agonist to estrogen receptors in bone and an antagonist to estrogen receptor in the breast

Question 14

Buprenorphine

Answer 14

Partial agonist with high affinity for Mu-opoid receptor maybe be more potent but less efficacious then full agonist (morphine)

Question 15

Pindolol

Answer 15

Often classified as a beta blocker but is actually a partial agonist that produces intermediate response.
Resting heart rate and blood pressure no reduced as well as pure antagonists, but pindolol inhibits potentially dangerous increases that would occur w/ sympathetic stimulation.

Question 16

Antagonist

Answer 16

Inhibits the action of an agonist. Has no effect in the absence of the agonist.

Question 17

Chemical antagonists

Answer 17

Inactivate agonist before it has the opportunity to act

Question 18

Physiological antagonists

Answer 18

cause a physiologic effect opposite to that induced by the agonist

Question 19

Competitive antagonist

Answer 19

Binds, reversibly to the active site of a receptor, and does not cause activation. Shifts to right

Question 20

Noncompetitive antagonist

Answer 20

Bind to either active or allosteric site of receptor. If bound to active site the binding is irreversible and cannot be outcompeted by agonist. Allosteric agonist acts by preventing receptor activation. Maximal efficacy of agonist is reduced.

Question 21

Therapeutic window

Answer 21

Range of doses of drug that elicits therapeutic response without unacceptable toxicity.

Question 22

Drug-drug interactions

Answer 22

Drugs w/ similar characteristics may produce an exaggerated response.
Drugs w/ opposing pharmacodynamic effects may cause a diminished or lack of response.