Pharmaceuticals Flashcards
What did the comprehensive drug abuse prevention & control act of 1970 establish?
US drug policy in which manufacturer, importation, possession, use, or distribution of certain substances is regulated
What are schedules based on?
-probability of drug abuse
-1 being most likely & schedule 5 is least likely
what is the FDA responsible for?
-protecting public health by assuring the safety, ethics, & security of human & veterinary drugs, biological products, medical devices, the nations food supply, cosmetics, & products that emit radiation
-comes up with the rules
Drug Enforcement Agency (DEA)-
-US law enforcement agency under the department of justice, tasked with combatting drug trafficking, distribution, & is lead agency for controlled substances act
-enforces the rules
DEA & FDA determines-
which substances are included on different schedules
Pharmaceutical waste-
any pharmaceutical products designated for disposal, no longer used, or unable to be returned to manufacturer (including viles, syringes, IV’s, & tubing
Hazardous Waste (5)-
-red
-black
-blue
-yellow
-no specific color
red HW-
sharps containers (needles & syringes)
black HW-
hazardous waste container
blue HW-
non-hazardous waste container
yellow HW-
chemotherapy related
no specific color HW-
controlled substance container deactivates all forms of controlled substances while in the container
AC-
before meals
BID-
2x daily
C-
with
H-
hour
IM-
intramuscular
IV-
intraavenously
mL-
millileter
mg-
miligram
PO-
by mouth
prn-
as needed
qh-
every hour
q2h-
every 2 hours
q3h-
every 3 hours
qid-
4x daily
S-
without
SC-
subcutaneous
stats-
immediately
tid-
3x daily
cc-
replaced by
OD-
1x daily
peroz-
replaced
Pharmacodynamics-
study of all effects of drugs
What are some pharmacodynamic effects?
-therapeutic
-adverse
-side affects
What are adverse affects of drugs?
negative affect
What are side affects of drugs?
-acts on another part of the body other than intended for
-allergic reaction, onset, & termination of action
3 ways drugs are classified-
name, action, & method of legal purchase
3 drug classifications by name?
chemical, generic, & brand
chemical name of drugs-
elements that make up that drug
generic name/non-proprietary name of drugs
name given to a drug after it’s made commercially available
brand name/proprietary/trademark name of drugs-
name given to a drug by the company who manufactured it
How are drugs classified by action?
groups of drugs that have similar actions
What is another name for drugs that are classified by action?
drug families (ex.- pain relievers)
Why could drugs be listed in more than one family?
because they have different affects or they’re for different body parts
classification by method of legal purchase-
can be bought over the counter (OTC) or have to have prescription
Drug references- (6)
-Physicians’ Desk Reference (PDR)
-United States Pharmacopeia (USP)
-National Formulary (NF)
-American Hospital Formulary Services (AHFS)
-Drug Facts & Comparisons (DFC)
-Mosby’s Gen Rx
Biopharmaceuticals-
-study of physical & chemical properties of a drug
-is dosage formed
What do biopharmaceuticals have relation to? (3)
-onset
-duration
-intensity of action
Drug Half-Life-
period of time it takes for drugs is reduced by 1/2
When do most drugs stop having an affect?
after 4-5 half-lives
therapeutic ratio-
compares blood concentration at which drug becomes toxic & concentration at which drug becomes therapeutic (therapeutic index- TI)
The larger the TI, the __ the drug.
the safer the drug
Pediatric Dosages-
safer dosages calculated according to Childs body weight in kg
What is a safer way to calculate pediatric dosages?
calculating by body surface area
dosage forms-
refers to a type of preparation in which the drug is transported into the body
types of dosage forms- (7)
tablet, capsule, inhalant, suppository, solution, suspension, & transdermal patch
tablet dosage form-
-most common in oral dosage
-loznge (cough drop) is a tablet that dissolves in the mouth
capsule dosage form-
has a gel coding that dissolves & releases contents when in the stomach
inhalant dosage form-
concentration of meds. delivered into respiratory system
suppository dosage form-
used for rectum, vagina, or urethra
solution dosage form-
dosage in which 1 or more drugs is dissolved in a liquid carrier
suspension dosage form-
when drug is suspended in a liquid carrier, they don’t dissolve
transdermal patch dosage form-
applied to skin & the drug is absorbed through the skin & into the blood stream
pharmacokinetics-
study of drugs motility through the body
disintegration-
how substances are broken down to improve their solubility
dissolution-
process in which substance dissolves in a solvent to produce a solution
absorption-
how drugs moves from where it enters the body & into the blood stream
distribution-
movement of a drug from the blood stream to the part of the body it’s intended to go to
metabolism-
how the body breaks down drugs & excretes it
excretion-
how drugs exit the body
2 routes of drug administration-
enteral & parenteral
enteral travels-
via the GI tract
parenteral travels-
by anything else
enteral drugs administered-
orally
buccal-
placed between the cheek & upper/lower jaw
sublingual-
placed under the tongue
ways enteral is administered orally- (4)
-buccal
-sublingual
-NG/Gastric tube
-rectal
parenteral administered-
applied directly to the skin
topical-
applied directly onto the skin (transdermal patch)
inhalation-
into the respiratory system (inhaler)
intradermal injection-
injected into 1 of the layers of skin (not all the way through)
subcutaneous-
below the epidermal layers
intramuscular injection-
through the skin & into the muscle
intravenous-
inside the vein
intrathecal-
place needle into subarachnoid space of the spine
ways parenteral drugs can be administered- (7)
-topical
-subcutaneous
-inhalation
-intradermal injection
-intramuscular injection
-intravenous
-intrathecal
before administering any drugs to a patient ask yourself-
-right drug?
-right amount?
-right time?
-right patient?
-right route?
how many times should you check the drug before administering it to the patient?
3x
informed consent-
must be obtained when a person has an invasive procedure (going into the body) done
pre- & post- procedural assessments-
-pre- evaluate the patient when they get there
-post- make sure patient isn’t having any affects
medication errors-
-also called preventable adverse drug events
-patient takes medication & an error is made & harm results to patient (5 R’s help avoid)
Drug action indications-
refers to use of a drug for treating a particular disease
Drug action contraindications-
any condition that renders particular line of treatment improper/undesirable
D-
Drowsiness
H-
Habit forming
I-
Interaction
X: SOS-
absolute contraindication/drug interaction
ASA-
Contains aspirin
C-
Caution
G-
Glaucoma
S-
Diabetes
Adrenergic blocking agent-
going to block hormone epinephrine or adrenaline (blocks BP & lowers heart rate)
Antimicrobials-
prohibiting bacteria, parasites, & viruses
Antibiotics-
refers to compound isolated from living orgs. that kills/inhibits growth of another org.
anticholinergics-
used to treat conditions that affect relaxation/contraction of muscles (Parkinson’s)
Antipsychotics-
treat symptoms of sycosis; delusions, paranoia
Antipyretics-
Reduce fever
Barbiturates-
Depressants
Emetic-
Induce vomiting
opioids/opioid antagonist-
oxy, molly, hydrocodone