Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

54 CNS > Pharmaceutical Technology > Flashcards

Pharmaceutical Technology Flashcards

1
Q

Types of transport

A
  • Transcellular
  • Paracellular
  • Intraneuron
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Properties of transcellular transport

A
  • Active mechanisms
  • Slow (>13 hours)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Properties of paracellular transport

A
  • Passive transport through gaps
  • Rapid
  • High turnover of olfactory sensory neurons can leave more gaps
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Advantages of intranasal delivery

A
  • Non-invasive
  • Can be self administered
  • Bypass hepatic 1st pass effect
  • Short onset of action
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Name the 7 barriers in intranasal delivery

A
  • Nasal epithelial layer
  • Nasal mucus (~5um)
  • Metabolic enzymes
  • Efflux pump
  • Hair
  • Mucociliary clearance
  • Volume
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lipinski’s rule of 5: ≤ 5 __________

A

Hydrogen bonds donors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Lipinski’s rule of 5: ≤ 10 ___________

A

Hydrogen bond acceptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lipinski’s rule of 5: size

A

<500 Da
- < 300 Da for N2B access of hydrophilic drugs
- <1 kDa for N2B access of lipophilic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Lipinski’s rule of 5: logP

A

<5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lipinski’s rule of 5: ionised or unionised?

A

unionised

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the excipient function of edetate disodium?

A

Metal chelator/preservative enhancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the excipient function of chlorobutanol?

A

Preservative

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the excipient function of ethanol?

A

Solvent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the excipient function of glycerin/glycerol?

A

Solvent/tonicity adjustment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the excipient function of glycine?

A

Solvent/tonicity adjustment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the excipient function of PEG?

A

Solvent

17
Q

What is the excipient function of PG?

A

Solvent

18
Q

What is the excipient function of saccharin sodium?

A

Sweetener

19
Q

What is the excipient function of lecithin?

A

Surfactant

20
Q

What is the excipient function of polysorbate 20&80?

A

Surfactant

21
Q

What is the excipient function of tyloxapol?

A

Surfactant

22
Q

What is the excipient function of Na CMC?

A

Viscosity adjustment

23
Q

What is the excipient function of benzyl alcohol?

A

Preservative

24
Q

Containers should not have _________.

A

Chemical or physical interactions with drug and excipient

25
Q

Containers should ___________.

A

Protect formulation from contamination and degradation

26
Q

Requirements of nasal spray delivery device

A
  • Stability with formulated product
  • User friendly design for patient compliance
  • Reliability in use
27
Q

Considerations for device design (6)

A
  • Droplet size distribution
  • Viscosity
  • Spray pattern
  • Plume geometry
  • Dose volume
  • Velocity
28
Q

Advantages of powder

A
  • Blowing through mouth avoids negative pressure and traps powder in nasal cavity
  • Less loss of drug
29
Q

Disadvantage of powder

A
  • May cause irritation
30
Q

How are in situ gels activated?

A

By stimulus such as change in
- pH
- temperature
- salt concentrations

54 CNS (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions