Pharma tx for dyslipidemia

Question 1

High intensity therapy lowers LDL by ___%

Answer 1

> 50%

Question 2

Moderate intensity therapy lowers LDL by __%

Answer 2

30-50%

Question 3

Low intensity therapy lowers LDL by __%

Answer 3

<30%

Question 4

2 statins used in high-intensity therapy

Answer 4

Atorvastatin 40-80 mg

Rosuvastatin 20 mg

Question 5

Give 1 low-intensity statin

Answer 5

Simvastatin 10 mg
Pravastatin 10-20 mg
Lovastatin 20 mg
Fluvastatin 20-40 mg
Pitavastatin 1 mg

Question 6

HMG-CoA reductase inhibitor; inhibits melavonate

Answer 6

Statins

Question 7

A/E of statins

Answer 7

myopathy, ALT/AST elev (reversible)

Question 8

Cholesterol absorption inhibitor

Answer 8

Ezetimibe

Question 9

A/E of ezetimibe

Answer 9

AST/ ALT elev

Question 10

Bile acid sequestrant

Answer 10

Cholestyramine

Question 11

A/E of cholestyramine

Answer 11

Gi discomfort, dec absorption of fat-soluble vit, CI if TG >200 (relative) or 500 (absolute)

Question 12

Upregulates lipoprotein lipase w/c increases hydrolysis of VLDL and chylomicrons

Answer 12

Fibrates (Gemfibrozil, fenofibrate)

Question 13

A/E of fibrates

Answer 13

Nausea, myositis, ALT/AST elev

Question 14

Enhances activity of lipoprotein lipase, leading to dec VLDL and TG levels

Answer 14

Niacin

Question 15

Only agent proven to raise HDL levels

Answer 15

Niacin

Question 16

Dec catabolism of chylomicrons and inc affinity of LDL uptake

Answer 16

Omega-3-FA (Fish Oil)

Question 17

A/E of Niacin

Answer 17

Flushing, hyperuricemia, IGT

Question 18

A/E of Omega-3-FA

Answer 18

Dyspepsia

Question 19

Inc rate of LDL catabolism w/ strong anti-oxidant properties

Answer 19

Probucol

Question 20

A/E of probucol

Answer 20

QT interval