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EJJB Pharma > Pharma Topic List B > Flashcards

Pharma Topic List B Flashcards

1
Q

B.3. Cholinomimetics - Drugs

A

carbachol
pilocarpine
neostigmine
pyridostigmine
rivastigmine
edrophonium

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2
Q

B.3. Cholinomimetics - Effects

A

i.e. parasympathomimetics – Rest and Digest
Eye - contraction of iris sphincter and ciliary m.
Salivary - inc secretion
Heart - inc vagal - negative chronotropy, dromotropy, inotropy
BV - dec BP - smooth muscle relaxation
Lungs - Bronchoconstriction
Stomach - inc gastric secretion
Intestine - inc motility
Urinary Tract - alleviate retention

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3
Q

B.3 Cholinmemtics - AChEi poisoning

A

DUMBBELS
D - diarrhea
U - urination
M - miosis
B - bradycardia
B - bronchoconstriction
E - excitation - CNS, muscles
L - lacrimation
S - secretion - sweating, salivation

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4
Q

carbachol

A

Is a synthetic choline ester
Direct acting cholinomemtic that is highly resistant to AchE hydrolysis

Acts on both N and M - not specific so rarely used
4˚ amine - no BBB
Topical - eyedrops
t1/2= 1 hr

tx: Acute Angle Glaucoma - opens canal of Schlemm

SE - CV and GI effect - stimulates and then depresses
N-R can cause release of E from adrenal medulla

B.3. Cholinomimetics

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5
Q

pilocarpine

A

Direct acting Cholinomimetic - Alkaloid so it is specific for muscarinic - Muscarinic Agonist
3˚ amine Yes BBB

Resistance to AchE hydrolysis
PO (eyedrops), Parentral
DoA - 30 min - 2h

Tx - Xerostoma from Sjøgren - systemic
DoC - glaucoma

OD- Antidote Atropine

B.3. Cholinomimetics

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6
Q

neostigmine

A

Indirect Acting Cholinomimetic
Non-competitive AchEi
4˚amine - no BBB

its a carbamate
main site of action is NMJ
IV - poor absorption in GI

tx: non-obstructive ileus, urinary retention
Used as an antidote for non-depolarizing curare like drugs post-op

CI - intestinal or urinary obstruction

B.3. Cholinomimetics

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7
Q

pyridostigmine

A

Indirect acting - Non-competitive AchEi
4˚amine - NO BBB
PO
DoA = 3-6hr
Main site of action - NMJ

tx: DoC for Myasthenia Gravis
paralytic ileus, urinary bladder atony
can be used against nerve gases

B.3. Cholinomimetics

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8
Q

rivastigmine

A

Non-Competitive AchEi - Indirect acting Cholinomemtic

Long acting t1/2 = ±70 hr
lipid soluble - YES BBB
hydrolyzed to carbamylated metabolite - no interactions

tx: transdermal patch - Alzheimer’s
first line drug with Donepezil, Galantamine
can delay the progession but cannot stop the disease

SE - GI distresss, cholinergic sym subside with continuing use

B.3. Cholinomimetics

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9
Q

edrophonium

A

Competitive AchEi

Short acting t1/2 = 5-15 mins with rapid renal elimination
to short for therapeutic use
PO
4˚amine - limited to periphery

Used: Tensilon test for diagnosis of Myasthenia Gravis

If too much given - antidote with atropine

B.3. Cholinomimetics

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10
Q

B.4. Muscarinic receptor blocking drugs

A

atropine
scopolamine
butyl-scopolamine
ipratropium
procyclidine
solifenacin
cyclopentolate
tiotropium
oxybutinine

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11
Q

atropine

A

B.4. Muscarinic receptor blocking drugs

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12
Q

scopolamine

A

B.4. Muscarinic receptor blocking drugs

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13
Q

butyl-scopolamine

A

B.4. Muscarinic receptor blocking drugs

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14
Q

ipratropium

A

B.4. Muscarinic receptor blocking drugs

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15
Q

procyclidine

A

B.4. Muscarinic receptor blocking drugs

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16
Q

solifenacin

A

B.4. Muscarinic receptor blocking drugs

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17
Q

cyclopentolate

A

B.4. Muscarinic receptor blocking drugs

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18
Q

tiotropium

A

B.4. Muscarinic receptor blocking drugs

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19
Q

oxybutinine

A

B.4. Muscarinic receptor blocking drugs

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20
Q

B.5. Catecholamines - Drugs

A

epinephrine
norepinephrine
dopamine
isoprenalin
dobutamine

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21
Q

epinephrine

A

B.5. Catecholamines

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22
Q

norepinephrine

A

B.5. Catecholamines

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23
Q

dopamine

A

B.5. Catecholamines

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24
Q

isoprenalin

A

B.5. Catecholamines

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25
Q

dobutamine

A

B.5. Catecholamines

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26
Q

B.6. Indirect sympathomimetics. Selective Alpha2-agonists and drugs acting on the imidazoline receptors - Drugs

A

ephedrine
phenylephrine
clonidin
rilmenidine
methyldopa
oxymetazoline

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27
Q

ephedrine

A

B.6. Indirect sympathomimetics. Selective Alpha2-agonists and drugs acting on the imidazoline receptors

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28
Q

phenylephrine

A

B.6. Indirect sympathomimetics. Selective Alpha2-agonists and drugs acting on the imidazoline receptors

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29
Q

clonidin

A

B.6. Indirect sympathomimetics. Selective Alpha2-agonists and drugs acting on the imidazoline receptors

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30
Q

rilmenidine

A

B.6. Indirect sympathomimetics. Selective Alpha2-agonists and drugs acting on the imidazoline receptors

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31
Q

methyldopa

A

B.6. Indirect sympathomimetics. Selective Alpha2-agonists and drugs acting on the imidazoline receptors

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32
Q

oxymetazoline

A

B.6. Indirect sympathomimetics. Selective Alpha2-agonists and drugs acting on the imidazoline receptors

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33
Q

B.7. alpha-receptor antagonists - Drugs

A

prazosin
doxazosin
tamsulozin
urapidil
carvedilol
phentolamine

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34
Q

prazosin

A

B.7. alpha-receptor antagonists

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35
Q

doxazosin

A

B.7. alpha-receptor antagonists

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36
Q

tamsulozin

A

B.7. alpha-receptor antagonists

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37
Q

urapidil

A

B.7. alpha-receptor antagonists

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38
Q

carvedilol

A

B.7. alpha-receptor antagonists

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39
Q

phentolamine

A

B.7. alpha-receptor antagonists

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40
Q

B.8. Beta-receptor antagonists - Drugs

A

propranolol
pindolol
carvedilol
timolol
sotalol
metoprolol
bisoprolol
nebivolol
esmolol

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41
Q

propranolol

A

B.8. Beta-receptor antagonists

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42
Q

pindolol

A

B.8. Beta-receptor antagonists

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43
Q

carvedilol

A

B.8. Beta-receptor antagonists

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44
Q

timolol

A

B.8. Beta-receptor antagonists

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45
Q

sotalol

A

B.8. Beta-receptor antagonists

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46
Q

metoprolol

A

B.8. Beta-receptor antagonists

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47
Q

bisoprolol

A

B.8. Beta-receptor antagonists

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48
Q

nebivolol

A

B.8. Beta-receptor antagonists

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49
Q

esmolol

A

B.8. Beta-receptor antagonists

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50
Q

B.9. Centrally acting skeletal muscle relaxants (spasmolytics). Dantrolene. Botulinum toxin - Drugs

A

baclofen
tolperisone
diazepam
tizanidine
dantrolene
botulinum toxin

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51
Q

baclofen

A

B.9. Centrally acting skeletal muscle relaxants (spasmolytics). Dantrolene. Botulinum toxin

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52
Q

tolperisone

A

B.9. Centrally acting skeletal muscle relaxants (spasmolytics). Dantrolene. Botulinum toxin

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53
Q

diazepam

A

B.9. Centrally acting skeletal muscle relaxants (spasmolytics). Dantrolene. Botulinum toxin

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54
Q

tizanidine

A

B.9. Centrally acting skeletal muscle relaxants (spasmolytics). Dantrolene. Botulinum toxin

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55
Q

dantrolene

A

B.9. Centrally acting skeletal muscle relaxants (spasmolytics). Dantrolene. Botulinum toxin

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56
Q

botulinum toxin

A

B.9. Centrally acting skeletal muscle relaxants (spasmolytics). Dantrolene. Botulinum toxin

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57
Q

B.10. Skeletal muscle relaxants acting on the neuromuscular junction - Drugs

A

atracurium
cisatracurium
mivacurium
pipecuronium
rocuronium
succynylcholine (suxamethonium)

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58
Q

atracurium

A

B.10. Skeletal muscle relaxants acting on the neuromuscular junction

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59
Q

cisatracurium

A

B.10. Skeletal muscle relaxants acting on the neuromuscular junction

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60
Q

mivacurium

A

B.10. Skeletal muscle relaxants acting on the neuromuscular junction

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61
Q

pipecuronium

A

B.10. Skeletal muscle relaxants acting on the neuromuscular junction

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62
Q

rocuronium

A

B.10. Skeletal muscle relaxants acting on the neuromuscular junction

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63
Q

succynylcholine (suxamethonium)

A

B.10. Skeletal muscle relaxants acting on the neuromuscular junction

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64
Q

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD. - Drugs

A

salbutamol
terbutaline
fenoterol
salmeterol
formoterol
ipratropium
tiotropium
theophyllin

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65
Q

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD. - Pharma of Bronchial Asthma

A

chronic inflam disease of airways with bronchoconstriction, dyspnea, cough, chest rightness, wheezing.

Goal of tx – reduce intensity and frequency of sympt and limitation caused by them.
Quick relief, long term – reverse and prevent airway inflam.
Steps to tx –
1. Assess severity and start tx accord to guideline.
2. Inc intensity of tx stepwise until well controlled
3. Dec dose of anti-inflam gradually.

1st stage – mild – SABA inhaler, or anitmusc inhal or oral SABA – symps 1x week, nighttime 2x/month FEV1>80%.
2nd stage – mild, persistent – reliever + small dose steroid inhaler or leukotriene inhib – symp 2x/week more than 2x night and FEV1>80%.
3rd stage – moderate, persistent. Reliever+small dose steroid+LABA – daily symp and FEV1 60-80%. 4th stage – severe and persistent. Reliever+med/high dose steroid +LABA.

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66
Q

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD. - Pharma of COPD

A

chronic irreversible obstruction of airflow that is progressive.

Tx depends on patient category.
A – SAMA/SABA can add LABA or theophylline.
B – LAMA/LABA can add SABA or theophylline.
C-ICS+LABA can add PDE4 inhibitor or theophylline.
D – ICS+LABA can add PDE4i, carbocysteine or theophylline.

ICS inhaled corticosteroids

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67
Q

salbutamol

A

Short acting beta2 agonist – Gs – inc [cAMP] – smooth m relax – bronchodilation

T1/2 – 4 hr, OoA 5 min. aerosol, nebulizer, parenteral.

TX – asthma, COPD, no prophylaxis. SE – tachycardia, tremor, arrhythmia

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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68
Q

terbutaline

A

Short acting beta2 agonist – Gs – inc [cAMP] – smooth m relax – bronchodilation

T1/2 – 4 hr, OoA 5 min. aerosol, nebulizer, parenteral.

TX – asthma, COPD, no prophylaxis. SE – tachycardia, tremor, arrhythmia

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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69
Q

fenoterol

A

Short acting beta2 agonist – Gs – inc [cAMP] – smooth m relax – bronchodilation

T1/2 – 4 hr, OoA 5 min. aerosol, nebulizer, parenteral.

TX – asthma, COPD, no prophylaxis. SE – tachycardia, tremor, arrhythmia

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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70
Q

salmeterol

A

Long acting beta2 agonist.
DoA 12-24 hr.
PO, aerosol, nebulizer, parenteral.

TX – bronchodilation in asthma, COPD, prophylaxis – beneficial when used with corticosteroids.

SE – tachycardia, tremor, arrythmia

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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71
Q

formoterol

A

Long acting beta2 agonist.
DoA 12-24 hr.
PO, aerosol, nebulizer, parenteral.

TX – bronchodilation in asthma, COPD, prophylaxis – beneficial when used with corticosteroids.

SE – tachycardia, tremor, arrythmia

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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72
Q

ipratropium

A

SAMA – muscarinic antagonist. Competitive inhibitor of M3R (Gq) – prevents bronchoconstriction mediated by vagal discharge.
Aerosol.
Onset <15 min DoA 4-6h – admin 3/day.

TX – asthma, COPD – beneficial for patients with cardiac disease.

SE – dry mouth, cough

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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73
Q

tiotropium

A

LAMA – M3 antagonist. Aerosol. Longer acting.

TX – asthma, COPD

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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74
Q

theophyllin

A

PDE3 inhibitor – prevents the breakdown of cAMP – inc cAMP in smooth muscle cells leading to bronchodilation.
Methylaxanthine derivative.
PO, slow release.
DOA 12 hr. hepatic CYP450.

TX – asthma – prophylaxis in nocturnal attacks, AHF, anti-inflamm.

SE – GI distress, insomnia, tremor, anorexia, seizures, cardiac stimulation chon and ino, arrythmia, CNS

B.11. Selective Beta2-stimulants and other bronchodilators. Pharmacotherapy of bronchial asthma and COPD.

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75
Q

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants - Drugs

A

prednisolone
methylprednisolon
fluticazone
budesonide
montelukast
omalizumab
codein
butamirate
prenoxdiazine
acetylcystein
bromhexin

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76
Q

prednisolone

A

inhaled GC.

TX – severe asthma – can use systemic PO.

Most effective anti-inflam agent used in asthma.
Inhibits PLA2 – dec COX – dec inflame mediators, dec inflame cells in airway, dec eosinophils dec activated T cells and mast cells.
Inc beta-2 R expression.

SE – infection – oral candiasis, hyperglycemia, Cushings

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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77
Q

methylprednisolon

A

inhaled GC.
TX – severe asthma – can use systemic PO.
Most effective anti-inflam agent used in asthma.
Inhibits PLA2 – dec COX – dec inflame mediators, dec inflame cells in airway, dec eosinophils dec activated T cells and mast cells.
Inc beta-2 R expression.

SE – infection – oral candiasis, hyperglycemia, Cushings

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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78
Q

fluticazone

A

inhaled GC for asthma and COPD

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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79
Q

budesonide

A

Topical GC tx bronchial asthma, allergic rhinitis. Enema- IBD

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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80
Q

montelukast

A

selective antagonist of CysLT1 Receptor which dec LDT4 (leukotriene D4).
Prevents Leukotrienes binding to receptor – dec bronchoconstriction and inflamm.
Smooth muscle relaxant.

TX – exercise induced asthma, long term maintenance.

SE – upper resp infect, headache, fever.

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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81
Q

omalizumab

A

(humanized) – Anti-IgE antibody.
Binds the Fc portion of the IgE Ab – binding to high affinity R on mast cells is prevented – dec inflamm response to inhaled antigens.
EXPENSIVE. Parenteral.

TX – prophylaxis of severe refractory asthma, that doesn’t respond to other drugs

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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82
Q

codein

A

mu opioid R agonist.
Antitussive, analgesic effect.

Weak semi-synthetic morphine agonist – suppresses cough reflex. 10% of codeine is transformed into morphine by CYP2D6.

SE – constipation, dependence

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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83
Q

butamirate

A

non-opioid centrally acting antitussive – suppresses cough reflex. PO.

Peripheral effect – bronchodilation, suppress inflamm. TX – cough

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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84
Q

prenoxdiazine

A

antitussive that acts on periphery. Dec receptor sensitivity, dec sensitivity of afferent nerves, inhibit cough reflex.

Works as local anesthetic in bronchoscopy.

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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85
Q

acetylcystein

A

mucolytic expectorant. Cleaves mucopolysacc and glucopro of mucus – diluting the mucus and dec viscosity.
Has thiol group – cleaves disulfide bridges.
TX – CF, chronic bronchitis, bronchiectasis.

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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86
Q

bromhexin

A

mucolytic expectorant. Inc the production of serous fluid in the resp tract, which makes phlegm thinner. PO

TX – CF, chronic bronchitis, bronchiectasis

B.12. Antiinflammatory agents used in bronchial asthma. Antitussive agents and expectorants

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87
Q

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine - Drugs

A

vinpocetin
nicergolin
cilostazol
pentoxifyllin
Ca-dobesilate
sumatriptan
galkanezumab
cinnarizin
propranolol
verapamil
carbamazepine
valproate
imipramine

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88
Q

vinpocetin

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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89
Q

nicergolin

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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90
Q

cilostazol

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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91
Q

pentoxifyllin

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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92
Q

Ca-dobesilate

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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93
Q

sumatriptan

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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94
Q

galkanezumab

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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95
Q

cinnarizin

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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96
Q

propranolol

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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97
Q

verapamil

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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98
Q

carbamazepine

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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99
Q

valproate

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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100
Q

imipramine

A

B.13. Drugs used for the treatment of peripheral vascular diseases. Therapy of migraine

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101
Q

B.14. Drugs used for treatment of heart failure I: Drugs decreasing the load on the heart. Drugs of acute cardiac failure. Pharmacotherapy of chronic heart failure. - drugs

A

ACE-inhibitors, diuretics, beta-blockers

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102
Q

B.15. Drugs used for treatment of heart failure II: Positive inotropic agents. Pharmacotherapy of acute heart failure. - Drugs

A

digoxin
digitoxin
milrinone
levosimendan
dobutamine

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103
Q

digoxin

A

B.15. Drugs used for treatment of heart failure II: Positive inotropic agents. Pharmacotherapy of acute heart failure

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104
Q

digitoxin

A

B.15. Drugs used for treatment of heart failure II: Positive inotropic agents. Pharmacotherapy of acute heart failure

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105
Q

milrinone

A

B.15. Drugs used for treatment of heart failure II: Positive inotropic agents. Pharmacotherapy of acute heart failure

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106
Q

levosimendan

A

B.15. Drugs used for treatment of heart failure II: Positive inotropic agents. Pharmacotherapy of acute heart failure

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107
Q

dobutamine

A

B.15. Drugs used for treatment of heart failure II: Positive inotropic agents. Pharmacotherapy of acute heart failure

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108
Q

B.16. Antiarrhytmic agents - Drugs

A

lidocaine
propafenone
esmolol
amiodarone
sotalol
verapamil
adenozine
digoxin
Mg++

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109
Q

lidocaine

A

B.16. Antiarrhytmic agents

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110
Q

propafenone

A

B.16. Antiarrhytmic agents

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111
Q

esmolol

A

B.16. Antiarrhytmic agents

112
Q

amiodarone

A

B.16. Antiarrhytmic agents

113
Q

sotalol

A

B.16. Antiarrhytmic agents

114
Q

verapamil

A

B.16. Antiarrhytmic agents

115
Q

adenozine

A

B.16. Antiarrhytmic agents

116
Q

digoxin

A

B.16. Antiarrhytmic agents

117
Q

Mg++

A

B.16. Antiarrhytmic agents

118
Q

B.17. Drugs used for the treatment of hypertension I: Classification of antihypertensive agents
and their mechanisms of action. Pharmacotherapy of hypertension. - Drugs

A

sympatholytics
diuretics

119
Q

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators - Drugs

A

amlodipine
felodipine
nifedipine
nimodipine
verapamil
dihydralazine
bozentan
sildenafil

120
Q

amlodipine

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

121
Q

felodipine

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

122
Q

nifedipine

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

123
Q

nimodipine

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

124
Q

verapamil

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

125
Q

dihydralazine

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

126
Q

bozentan

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

127
Q

sildenafil

A

B.18. Drugs used for the treatment of hypertension II: Ca++-channel blockers and other vasodilators

128
Q

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system - Drugs

A

enalapril
perindopril
ramipril
losartan
valsartan
valsartan + sacubitril
irbesartan
spironolactone
eplerenon
captopril

129
Q

enalapril

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

130
Q

perindopril

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

131
Q

ramipril

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

132
Q

losartan

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

133
Q

valsartan

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

134
Q

valsartan + sacubitril

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

135
Q

irbesartan

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

136
Q

spironolactone

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

137
Q

eplerenon

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

138
Q

captopril

A

B.19. Drugs used for the treatment of hypertension III: Drugs acting on the renin-angiotensin-aldosterone system

139
Q

B.20. Drugs used for treatment of angina pectoris. Pharmacotherapy of ischemic heart disease. - Drugs

A

nitroglicerin
isosorbid-mononitrate
trimetazidine
ivabradin
beta-bockers and Ca-channel blockers

140
Q

nitroglicerin

A

B.20. Drugs used for treatment of angina pectoris. Pharmacotherapy of ischemic heart disease.

141
Q

isosorbid-mononitrate

A

B.20. Drugs used for treatment of angina pectoris. Pharmacotherapy of ischemic heart disease.

142
Q

trimetazidine

A

B.20. Drugs used for treatment of angina pectoris. Pharmacotherapy of ischemic heart disease.

143
Q

ivabradin

A

B.20. Drugs used for treatment of angina pectoris. Pharmacotherapy of ischemic heart disease.

144
Q

B21. Agents used in dyslipidaemias. - Drugs

A

simvastatin
atorvastatin
rosuvastatin
ezetimib
fenofibrate
colesevelam

145
Q

simvastatin

A

B21. Agents used in dyslipidaemias

146
Q

atorvastatin

A

B21. Agents used in dyslipidaemias

147
Q

rosuvastatin

A

B21. Agents used in dyslipidaemias

148
Q

ezetimib

A

B21. Agents used in dyslipidaemias

149
Q

fenofibrate

A

B21. Agents used in dyslipidaemias

150
Q

colesevelam

A

B21. Agents used in dyslipidaemias

151
Q

B.22. Potassium excreting (wasting) diuretics - Drugs

A

acetazolamide
hydrochlorothiazide
indapamide
furosemide
etacrynic acid

152
Q

acetazolamide

A

B.22. Potassium excreting (wasting) diuretics

153
Q

hydrochlorothiazide

A

B.22. Potassium excreting (wasting) diuretics

154
Q

indapamide

A

B.22. Potassium excreting (wasting) diuretics

155
Q

furosemide

A

B.22. Potassium excreting (wasting) diuretics

156
Q

etacrynic acid

A

B.22. Potassium excreting (wasting) diuretics

157
Q
  1. Potassium sparing diuretics, ADH antagonists, osmotic diuretics - Drugs
A

spironolactone
eplerenone
amiloride
tolvaptan
mannitol
glycerol

158
Q

spironolactone

A
  1. Potassium sparing diuretics, ADH antagonists, osmotic diuretics
159
Q

eplerenone

A
  1. Potassium sparing diuretics, ADH antagonists, osmotic diuretics
160
Q

amiloride

A
  1. Potassium sparing diuretics, ADH antagonists, osmotic diuretics
161
Q

tolvaptan

A
  1. Potassium sparing diuretics, ADH antagonists, osmotic diuretics
162
Q

mannitol

A
  1. Potassium sparing diuretics, ADH antagonists, osmotic diuretics
163
Q

glycerol

A
  1. Potassium sparing diuretics, ADH antagonists, osmotic diuretics
164
Q

B.24. Histamine and antihistamines. - drugs

A

promethazine
diphenhydramine
cetirizine
levocetirizine
loratadine
desloratadine
dimetinden
fexofenadin

165
Q

promethazine

A

B.24. Histamine and antihistamines

166
Q

diphenhydramine

A

B.24. Histamine and antihistamines

167
Q

cetirizine

A

B.24. Histamine and antihistamines

168
Q

levocetirizine

A

B.24. Histamine and antihistamines

169
Q

loratadine

A

B.24. Histamine and antihistamines

170
Q

desloratadine

A

B.24. Histamine and antihistamines

171
Q

dimetinden

A

B.24. Histamine and antihistamines

172
Q

fexofenadin

A

B.24. Histamine and antihistamines

173
Q

B.25. Natural opiates, opioid receptors - Drugs

A

morphine
codeine

174
Q

morphine

A

B.25. Natural opiates, opioid receptors

175
Q

codeine

A

B.25. Natural opiates, opioid receptors

176
Q

B.26. Semisynthetic and synthetic opiates - Drugs

A

hydromorphone
dihydrocodeine
oxycodone
buprenorphine
nalbuphine
meperidine =(pethidine)
fentanyl
methadone
tramadol
diphenoxylate
loperamide
naloxone
methyl-naltrexone

177
Q

hydromorphone

A

B.26. Semisynthetic and synthetic opiates

178
Q

dihydrocodeine

A

B.26. Semisynthetic and synthetic opiates

179
Q

oxycodone

A

B.26. Semisynthetic and synthetic opiates

180
Q

buprenorphine

A

B.26. Semisynthetic and synthetic opiates

181
Q

nalbuphine

A

B.26. Semisynthetic and synthetic opiates

182
Q

meperidine =(pethidine)

A

B.26. Semisynthetic and synthetic opiates

183
Q

fentanyl

A

B.26. Semisynthetic and synthetic opiates

184
Q

methadone

A

B.26. Semisynthetic and synthetic opiates

185
Q

tramadol

A

B.26. Semisynthetic and synthetic opiates

186
Q

diphenoxylate

A

B.26. Semisynthetic and synthetic opiates

187
Q

loperamide

A

B.26. Semisynthetic and synthetic opiates

188
Q

naloxone

A

B.26. Semisynthetic and synthetic opiates

189
Q

methyl-naltrexone

A

B.26. Semisynthetic and synthetic opiates

190
Q

B.27. General properties of NSAIDs. Acetylsalicylic acid. - Drugs

A

acetylsalicylsav
colchicin
allopurinol
rasburicase

191
Q

acetylsalicylsav

A

B.27. General properties of NSAIDs. Acetylsalicylic acid.

192
Q

colchicin

A

B.27. General properties of NSAIDs. Acetylsalicylic acid.

193
Q

allopurinol

A

B.27. General properties of NSAIDs. Acetylsalicylic acid.

194
Q

rasburicase

A

B.27. General properties of NSAIDs. Acetylsalicylic acid.

195
Q

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain. - Drugs

A

metamizole
naproxen
ibuprofen
ketoprofen
dexketoprofen
phenylbutazone
indomethacin
diclofenac
meloxicam
celecoxib
paracetamol

196
Q

metamizole

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

197
Q

naproxen

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

198
Q

ibuprofen

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

199
Q

ketoprofen

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

200
Q

dexketoprofen

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

201
Q

phenylbutazone

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

202
Q

indomethacin

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

203
Q

diclofenac

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

204
Q

meloxicam

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

205
Q

celecoxib

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

206
Q

paracetamol

A

B.28. NSAIDs, except acetylsalicylic acid. Non-opioid and adjuvant analgesics. Drugs used for treatment of gout. Treatment strategy of pain.

207
Q

B.29. Immunopharmacology I. (cytotoxic agents, retinoids). Pharmacotherapy of autoimmune diseases. - Drugs

A

cyclophosphamide
methotrexate
leflunomide
azathioprin
mycophenolate-mofetil

208
Q

cyclophosphamide

A

B.29. Immunopharmacology I. (cytotoxic agents, retinoids). Pharmacotherapy of autoimmune diseases.

209
Q

methotrexate

A

B.29. Immunopharmacology I. (cytotoxic agents, retinoids). Pharmacotherapy of autoimmune diseases.

210
Q

leflunomide

A

B.29. Immunopharmacology I. (cytotoxic agents, retinoids). Pharmacotherapy of autoimmune diseases.

211
Q

azathioprin

A

B.29. Immunopharmacology I. (cytotoxic agents, retinoids). Pharmacotherapy of autoimmune diseases.

212
Q

mycophenolate-mofetil

A

B.29. Immunopharmacology I. (cytotoxic agents, retinoids). Pharmacotherapy of autoimmune diseases.

213
Q

B.30. Immunopharmacology II. (Inhibitors of cytokine gene expression, 5-ASA derivatives) - drugs

A

cyclosporin A
tacrolimus
sirolimus
tofacitinib
sulfasalazine

214
Q

cyclosporin A

A

B.30. Immunopharmacology II. (Inhibitors of cytokine gene expression, 5-ASA derivatives)

215
Q

tacrolimus

A

B.30. Immunopharmacology II. (Inhibitors of cytokine gene expression, 5-ASA derivatives)

216
Q

sirolimus

A

B.30. Immunopharmacology II. (Inhibitors of cytokine gene expression, 5-ASA derivatives)

217
Q

tofacitinib

A

B.30. Immunopharmacology II. (Inhibitors of cytokine gene expression, 5-ASA derivatives)

218
Q

sulfasalazine

A

B.30. Immunopharmacology II. (Inhibitors of cytokine gene expression, 5-ASA derivatives)

219
Q

B.31. Immunopharmacology III. (Antibodies and fusion proteins) - Drugs

A

ATG (antithymocyte-globulin)
rituximab
infliximab
adalimumab
tocilizumab
ustekinumab
natalizumab
dupilumab
abatacept

220
Q

ATG (antithymocyte-globulin)

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

221
Q

rituximab

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

222
Q

infliximab

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

223
Q

adalimumab

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

224
Q

tocilizumab

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

225
Q

ustekinumab

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

226
Q

natalizumab

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

227
Q

dupilumab

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

228
Q

abatacept

A

B.31. Immunopharmacology III. (Antibodies and fusion proteins)

229
Q

B.32. Cancer chemotherapy I (antimetabolites) - Drugs

A

5-fluorouracyl
capecitabine
cytarabine
6-merkaptopurine
methotrexate
pemetrexed

230
Q

5-fluorouracyl

A

B.32. Cancer chemotherapy I (antimetabolites)

231
Q

capecitabine

A

B.32. Cancer chemotherapy I (antimetabolites)

232
Q

cytarabine

A

B.32. Cancer chemotherapy I (antimetabolites)

233
Q

6-merkaptopurine

A

B.32. Cancer chemotherapy I (antimetabolites)

234
Q

methotrexate

A

B.32. Cancer chemotherapy I (antimetabolites)

235
Q

pemetrexed

A

B.32. Cancer chemotherapy I (antimetabolites)

236
Q

B.33. Cancer chemotherapy II (alkylating agents) - Drugs

A

cyclophosphamide
dacarbazine
temozolomide
cisplatine
oxaliplatin
dactinomycin
bleomycin

237
Q

cyclophosphamide

A

B.33. Cancer chemotherapy II (alkylating agents)

238
Q

dacarbazine

A

B.33. Cancer chemotherapy II (alkylating agents)

239
Q

temozolomide

A

B.33. Cancer chemotherapy II (alkylating agents)

240
Q

cisplatine

A

B.33. Cancer chemotherapy II (alkylating agents)

241
Q

oxaliplatin

A

B.33. Cancer chemotherapy II (alkylating agents)

242
Q

dactinomycin

A

B.33. Cancer chemotherapy II (alkylating agents)

243
Q

bleomycin

A

B.33. Cancer chemotherapy II (alkylating agents)

244
Q

B.34. Cancer chemotherapy III (Topisomerase inhibitors. Inhibitors of mitotic spindle) - Drugs

A

irinotecan
etoposide
doxorubicin
vincristine
docetaxel

245
Q

irinotecan

A

B.34. Cancer chemotherapy III (Topisomerase inhibitors. Inhibitors of mitotic spindle)

246
Q

etoposide

A

B.34. Cancer chemotherapy III (Topisomerase inhibitors. Inhibitors of mitotic spindle)

247
Q

doxorubicin

A

B.34. Cancer chemotherapy III (Topisomerase inhibitors. Inhibitors of mitotic spindle)

248
Q

vincristine

A

B.34. Cancer chemotherapy III (Topisomerase inhibitors. Inhibitors of mitotic spindle)

249
Q

docetaxel

A

B.34. Cancer chemotherapy III (Topisomerase inhibitors. Inhibitors of mitotic spindle)

250
Q

B.35. Cancer chemotherapy IV. (Hormonal agents) - Drugs

A

tamoxifen
anastrozole
goserelin
degarelix
bicalutamide
prednisolone
octreotide

251
Q

tamoxifen

A

B.35. Cancer chemotherapy IV. (Hormonal agents)

252
Q

anastrozole

A

B.35. Cancer chemotherapy IV. (Hormonal agents)

253
Q

goserelin

A

B.35. Cancer chemotherapy IV. (Hormonal agents)

254
Q

degarelix

A

B.35. Cancer chemotherapy IV. (Hormonal agents)

255
Q

bicalutamide

A

B.35. Cancer chemotherapy IV. (Hormonal agents)

256
Q

prednisolone

A

B.35. Cancer chemotherapy IV. (Hormonal agents)

257
Q

octreotide

A

B.35. Cancer chemotherapy IV. (Hormonal agents)

258
Q

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors) - Drugs

A

imatinib
gefitinib
erlotinib
lapatinib
sunitinib
ibrutinib
crizotinib
bortezomib
dabrafenib+ trametinib
everolimus
tretinoin

259
Q

imatinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

260
Q

gefitinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

261
Q

erlotinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

262
Q

lapatinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

263
Q

sunitinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

264
Q

ibrutinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

265
Q

crizotinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

266
Q

bortezomib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

267
Q

dabrafenib+ trametinib

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

268
Q

everolimus

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

269
Q

tretinoin

A

B.36. Cancer chemotherapy V. (Small molecule signal transduction inhibitors)

270
Q
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors) - Drugs
A

trastuzumab (-emtansin)
panitumumab
rituximab
bevacizumab
alfa-interferon
aldesleukin
pembrolizumab

271
Q

trastuzumab (-emtansin)

A
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors)
272
Q

panitumumab

A
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors)
273
Q

rituximab

A
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors)
274
Q

bevacizumab

A
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors)
275
Q

alfa-interferon

A
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors)
276
Q

aldesleukin

A
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors)
277
Q

pembrolizumab

A
  1. Cancer chemotherapy VI. (Large molecule signal transduction inhibitors)

EJJB Pharma (4 decks)

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