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Pharma 3 > Pharma Collq3 > Flashcards

Pharma Collq3 Flashcards

1
Q

Non opioid analgesic are

A

Paracetamol and metamizol

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2
Q

Opioid receptor agonists are

A

Codaine, fentanyl, morphine, tramadol,buprenorphine

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3
Q

Coanalgesics

A

Anti epileptic drugs, antidepressants, central Aalpha adrenoreceptor agonist

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4
Q

5HT receptor agonists

A

Sumatriptan

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5
Q

Opioid receptor antagonist

A

Naloxone

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6
Q

NSAIDS

A

Ibuprofen and dickofenac

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7
Q

CGRP receptor antagonist

A

Erenumab

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8
Q

CGRP antagonist

A

Galcanezumab

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9
Q

Chronic pain are

A

Inflammatory pain, musculoskeletal pain, headache, neuropathy

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10
Q

Neuropathic pain is due to

A

Somatosensory nerve damage

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11
Q

Most common neuropathy

A

Post herpetic neuralgia, diabetic neuropathy, trigeminal neuralgia

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12
Q

Neuropathic pain has

A

Excessive sensitization of neurons and ectopic signal foci

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13
Q

Ectopic signal foci is caused by

A

Over expression of sodium channels

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14
Q

Against neuropathic pain

A

Anti epileptic and antidepressants drugs are used

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15
Q

For nociceptive pain

A

NSAIDS and paracetamol

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16
Q

Nociceptive system connect to

A

Spinothalamic and spinomedullary tract neurons

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17
Q

Classical or typical antipsychotic drugs

A

Haloperidol and chlorprothixene

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18
Q

Atypical (2.gen) drugs

A

Clozapine,Olanzapine,Quetiapine,Aripiprazole

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19
Q

Non specific antipsychotic drugs

A

Melperone and sulpiride

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20
Q

Psychotic states are

A

Schizophrenia and bipolar disorders

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21
Q

4groups of psychotic symptoms

A

Positive,negative, cognitive and affective

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22
Q

Positive symptoms are

A

Hallucinations, delusion and catatonia (stupor and excitement)

23
Q

Catatonic excitement

A

Chaotic, unpredictable, stereotypical psychomotor activity

24
Q

Negative symptoms are

A

Alogia,anhedonia, emotional indifference and social isolation

25
Q

Cognitive symptoms are

A

Attention and concentration disorder,working memory deficiency

26
Q

Affective symptoms are

A

Depression, anxiety and suicidality

27
Q

Division of AP into typical and atypical is based on

A

EPS historical,butewrong
Nowadays based on negative symptoms

28
Q

Drugs that cause disease independent negative symptoms are

A

Typical antipsychotic drugs

29
Q

4major pathways in dopaminergic system

A

Mesolimbic,mesocortical,nigrostriatal,tuberohypophseal(tuberoinfundibular)

30
Q

Drugs used against positive symptoms are

A

D2 receptor antagonist working on mesolimbic tract

31
Q

Typical drugs have

A

Prolonged D2 receptor blockade or slow off dissociation kinetics

32
Q

Typical drugs can cause

A

Negative symptoms as well

33
Q

D2 receptor blockade SE

A

EPS,hyperprolactinemia

34
Q

HT2a receptor blockade SE

A

Anxiety and insomnia

35
Q

H1receptor blocker SE

A

Drowsiness, appetite,weight gain

36
Q

M cholinoreceptor blocker SE

A

Dry mouth, urinary retention,blurry vision, constipation,can also cause negative and cognitive symptoms

37
Q

Alpha 1 adrenoreceptor blocker SE

A

Orthostatic hypotension, reflector tachycardia, dizziness

38
Q

H1 receptor blocker is used to gove

39
Q

Antiemetic

A

Against vomiting

40
Q

Typical AP indication

A

Schizophrenia and acute mania

41
Q

Atypical AP indication

A

Schizophrenia and bipolar disorders

42
Q

Aripiprazole is a

A

D2 partial agonist and HT2a antagonist

43
Q

Aripiprazole use

A

Schizophrenia, bipolar disorders and acute mania

44
Q

Clozapine main side effect

A

Agranulocytosis,convulsion ,severe constipation (it can also cause wet cushion syndrome due to M4 stimulation), sedation (H1 block), orthostatic hypotension due alpha 1 adrenoreceptor block))

45
Q

Clozapine is used only

A

Resistant schizophrenia treatment

46
Q

Melperone use

A

Schizophrenia and neurotic stage and confusion in seniors

47
Q

Sulpiride uses

A

Affect negative and affective symptoms without acting on 5HT 2a receptor ,so use in schizophrenia and depressive disorders

48
Q

Akathisia

A

Desire to move constantly

49
Q

Dystonia

A

Uncontrollable, abnormal involuntary movement

50
Q

Parkinsonism

A

Bradykinesia,tremor, rigidity

51
Q

EPS treatment

A

Trihexyphenidyl(central M cholino blocker)

52
Q

Metabolic disorders caused by AP

A

Weight gain, hyperprolactinemia, hypercholesterolemia,risk of diabetes

53
Q

Treatment of NMS

A

Benzodiazepine(against anxiety and agitation),central D2 receptor agonist -bromocriptine,Danteolene- peripheral muscle relaxant(against muscle rigidity and hyperthermia)

Pharma 3 (4 decks)

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