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Pharma 3 > Antiepileptic > Flashcards

Antiepileptic Flashcards

1
Q

Status seizures or status epilepticus

A

Continuous or repeated epileptic seizures for atleast 30 minutes without regaining consciousness in between

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2
Q

Different form of epilepsy

A

Focal, generalized, combined,forms of unknown origin

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3
Q

Generalized epilepsy two form

A

Grand mal(tonic clinic), petite mal Absence

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4
Q

Tonic seizures

A

Increase muscle tone

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5
Q

Clonic seizures

A

Increase muscle twitching

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6
Q

Vegetative seizures

A

Has peculiar epigastric sensation

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7
Q

Sodium channel blockers in antiepileptic

A

Carbamazepine, valproic acid , Lamotrigine, Topiramate

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8
Q

T type calcium channel blockers in antiepileptic

A

Ethosuximide and valproic acid

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9
Q

High voltage calcium channel blockers in antiepileptic

A

Gabapentin, Lamotrigine, Topiramate

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10
Q

GABA a receptor allosteric modulator

A

Phenobarbital and Topiramate

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11
Q

GABA transaminase inhibitor

A

Valproic acid

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12
Q

SV2A action in antiepileptic drigs

A

Levetiracetam

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13
Q

Ampa /kainate receptor antagonist

A

Topiramate

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14
Q

Focal epilepsy can be treated by

A

Phenobarbital, Gabapentin,, Carbamazepine, valproic acid, Lamotrigine, Topiramate and levetiracetam

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15
Q

Tonic clinic form is treatment

A

Phenobarbital, carbamazepine, valproic acid, Lamotrigine, Topiramate and levetiracetam

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16
Q

Absence epilepsy treatment

A

Ethosuximide and valproic acid, Lamotrigine

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17
Q

Status epilepticus treatment

A

Phenobarbital, valproic acid, levetiracetam

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18
Q

Ethosuximide is a

A

T type (low voltage calcium channel blocker , work only on absence seizures

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19
Q

Phenobarbital is a

A

GABA allosteric modulator,treats ,focal ,tonic clinic and status epilepticus

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20
Q

Gabapentin is a

A

High voltage calcium channel blockers,works only on Focal epilepsy

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21
Q

Carbamazepine is a

A

Sodium channel blocker,works only on Focal and tonic clinic epilepsy

22
Q

Lamotrigine is a

A

Sodium channel blocker and high voltage calcium channel blockers ,treats focal, tonic clonic and absence epilepsy

23
Q

Levetiracetam is a

A

SV2A antagonist,focal, tonic clonic and status epilepticus

24
Q

Topiramate is a

A

Sodium channel blocker and high v calcium channel blockers,GABA A allosteric modulator,AMPA receptor antagonist -focal epilepsy,Tonic clonic E

25
Q

Valproic acid

A

Na channel blocker,LV calcium channel blockers,GABA transaminase inhibitor,, treatment of all type of epilepsy

26
Q

Levetiracetam and phenobarbital can be used in treatment of

A

Focal, tonic clonic and status epilepticus

27
Q

Lamotrigine treat

A

Focal , Tonic clonic and absence

28
Q

Nti seizures drugs acting on status epilepticus

A

Diazepam, midazolam, valproic acid, phenobarbital, lorazepam levetiracetam

29
Q

SE valproic acid

A

Teratogenic effect

30
Q

Carbamazepine use

A

Bipolar disorders, neuropathic pain(trigeminal neuralgia), general TC and focal epilepsy

31
Q

Gabapentin use

A

Focal epilepsy, neuropathic pain(diabetic neuropathy and post herpetic neuralgia), chronic pain syndrome

32
Q

COMT inhibitor

A

Entacapone and tolcapone

33
Q

Central acting cholinoreceptor blocker

A

Trihexyphenidyl

34
Q

MAO inhibitor

A

Selegiline

35
Q

NMDA receptor antagonist

36
Q

Dopamine precursor or dopamine receptor agonists

A

Levodopa/benserazide,carbidopa,pramipexole

37
Q

Parkinsons disease symptoms

A

Tremor, bradykinesia rigidity,postural instability

38
Q

Carbidopa doesn’t cross

A

BBB and inhibits peripheral metabolism ofL-dopa,so that more dopamine available in CNS

39
Q

L dopa can be used as antiparkinsonian and al see o it reduces

40
Q

Carbidopa and benserazide are

A

Levodopa metabolism inhibitors or decarboxylase inhibitors

41
Q

Dopamine induced GIT SE

A

Nausea, vomiting

42
Q

Dopamine induced cardiovascular SE

A

Arrythmia and hypotension

43
Q

L dopa can cause

44
Q

Wearing off means

A

Exacerbation of disease

45
Q

On off phenomena

A

Acute cycles of exacerbation of symptoms throughout the day

46
Q

Levodopa induced dyskinesia

A

Involuntary movement during on time and bradykinesia during off time

47
Q

Levodopa use

A

Parkinson disease and Parkinsonism

48
Q

Trihexyphenidyl use

A

EPs, parkinsonism

49
Q

Antidementia agents

A

NMDA receptor antagonist -memantine
Anticholineserases-donezepil,rivastigmine

50
Q

SE of ACH esterase inhibitor

A

Cholinergic hyperactivation

51
Q

Use of donezapil

A

Alzheimer’s dementia, vascular dementia, Parkinson’s dementia

52
Q

NMDA receptor channel blocker memantine use

A

Alzheimer’s dementia

Pharma 3 (4 decks)

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