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Pharma 3 > Analgesic > Flashcards

Analgesic Flashcards

1
Q

Non opioid analgesic

A

Paracetamol and metamizol

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2
Q

Opioid receptor agonists

A

Morphine,codeine, Fentanyl, Tramadol, Buprenorphine

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3
Q

Coanalgesic are

A

Antiepileptic, antidepressants and central alpha adrenoreceptor agonist

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4
Q

Serotonin receptor agonist analgesic

A

Sumatriptan

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5
Q

Opioid receptor antagonist

A

Naloxone

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6
Q

NSAIDS

A

Diclofenac and ibuprofen

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7
Q

CGRP receptor antagonist analgesic

A

Erenumab

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8
Q

CGRP antagonist

A

Galcanezumab

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9
Q

Nociceptive pain

A

Damage to tissues other than nerves

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10
Q

Neuropathic pain cause

A

by damage of somatosensory nerve system or disease

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11
Q

Neuropathic pain characteristic

A

Excessive sensitization of neurons and formation of ectopic signals foci

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12
Q

Ectopic signal foci is caused by

A

Over expression of sodium channels

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13
Q

In nociceptive system they finally connect to

A

Spinothalamic and spinomedullary tract neurons

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14
Q

Anti nociceptive regulation is

A

Downward modulation

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15
Q

Stimulation of peraqueductive efferent tract leads to release of

A

Serotonin,NE and Encephalins,which block afferent pain impulse by substance p and glutamate

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16
Q

Three types of opioid receptor are

A

Mu,delta and kappa

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17
Q

MOA of opioid

A

Presynaptic calcium channel blockage and post synaptic potassium channel opening (hyperpolarization

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18
Q

Spinal analgesia reduce

A

afferent fiber signal transduction

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19
Q

Morphine acts on

A

Mu ,delta and kappa receptor and has analgesic and sedative effect

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20
Q

Morphine use

A

Traumatic pain, postoperative pain, tumor induced pain

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21
Q

Codeine

A

Weak mu receptor agonist, analgesic and sedative effect

22
Q

Codeine use

A

Moderate intensity pain

23
Q

Fentanyl

A

Mu and delta receptor agonists, partial kappa agonist, analgesic effect stronger than morphine and sedative effect (lipophilic,short acting)

24
Q

Fentanyl ise

A

Tumor pain

25
Q

Tramadol

A

Weak mu receptor agonist and analgesic effect enhanced by SNRI and SSRI,has analgesic and sedative effect

26
Q

Tramadol use

A

Moderate intensity pain

27
Q

Buprenorphine

A

Partial agonist of my and antagonist of kappa, analgesic and sedative effect

28
Q

Buprenorphine use

A

Abstinence of potential opioid receptor agonists and severe to moderate pain

29
Q

Side effects of opiods

A

Respiratory depression, nausea vomiting, pupillary constriction, suppression of cough, constipation, urinary retention, increase tone of sphincter of oddi,bradycardia, hypotension,itching

30
Q

Main side effects of opiods

A

Euphoria, addiction, abstinence, tolerance

31
Q

Symptoms triad of opiods receptor agonists toxicology

A

Respiratory depression,miosis,coma

32
Q

Naloxone action

A

On my kappa and delta,iV, short acting

33
Q

Naloxone

A

Reduce respiratory depression, limit abuse of buprenorphine,reduce risk of opioid induced constipation

34
Q

Paracetamol is

A

Prostaglandin H2 synthetase inhibitor,inhibition of COX 2 and COX 3,Inhibition of prostaglandin synthesis centrally

35
Q

Prostaglandin H2 synthetase is same as

A

Cyclooxygenase

36
Q

Paracetamol has

A

Antipyretic and analgesic effect with slight anti inflammatory effect

37
Q

Paracetamol use

A

Short term treatment of moderate intensity postoperative pain, symptomatic treatment of mild to moderate pain,fever

38
Q

SE of paracetamol

A

Liver failure, encephalopathy,coma

39
Q

Ethnol increase

A

Paracetamol toxicity

40
Q

Antidote for paracetamol toxicity

A

Acetylcysteine iv

41
Q

Metamizol effect

A

Inhibition of COX,antispasmodic effect

42
Q

SE of metamizol

A

Agranulocytosis

43
Q

Metamizol use

A

Severe to moderate intensity postoperative and post trauma pain,severe moderate intensity acute pain,fever

44
Q

Migrane

A

Unilateral, pulsating pain in forehead and temples.1-6 attack per month

45
Q

Sumatriptan is used for

A

Treatment of migraine attacks

46
Q

Galcanezumab and erenumab use

A

Migraine attack prophylaxis

47
Q

Clonidine uae

A

Adjuvant opioid therapy

48
Q

Carbamazepine use

A

N.trigeminus neuralgia

49
Q

Valproic acid use

A

Prevention of migraine attack

50
Q

Gabapentin use

A

Post herpetic neuralgia

51
Q

Amitriptyline ise

A

Fibromyalgia

52
Q

Amitriptyline ise

A

Fibromyalgia

Pharma 3 (4 decks)

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