Pharma

Question 1

Which drug cause drug induced SLE?

Type of antibody found?

Answer 1

-Isoniazide (INH)- An antitubercular drug

-Antihisone antibody

Question 2

Drugs used in chronic CCF?

Answer 2

ACE I/ ARB ➡️ to max tolerated dose -switch
to Sacubitril+Valsartan

⬇️
50%of max tolerated dose
Beta blocker
⬇️(if no response)
Spironolacton
⬇️(if no response)
Ivabradin
⬇️(if no response)
Hydralazine,IDN

Question 3

Side effects of DIGOXIN

Answer 3

1. Nausea and vomiting ( may be the sign of impending toxicity)
2. Xanthopsia (yellowish vision)
3. Gynacomastia
4. Hyperkalemia

Question 4

Only class of CCB used in arrhythmia?

Answer 4

Non dihydropyridine group
( VERAPAMIL>DILTIAZEM)

Question 5

CAPTOPRIL TEST

Answer 5

Done to diagnose RENOVASCULAR HTN
And differentiate from essential HTN
⬇️(if positive)
Renal angiography

Question 6

What is HTN Urgency

Answer 6

Bp >220/125mmHg
WITHOUT end organ damage
Tx - CLONIDINE (DOC)

(HTN emergency ass. with EOD irrespective of BP
Tx - iv NICARDIPIN ,, : LABATOLOL in pregnancy)

Question 7

Drugs used in HTN emergency

Answer 7

HELEN Dance
H -Hydralazine
E - Esmolol
L - Labetolol, Lasix
E - Enalapril
N - Nitroglycerin, Na nitroprusside
D - Dyhydropyridine

Question 8

PDE 5 not used with Sildena. Tadala.

Answer 8

PDE 5 inhibited by them

Eg.

Question 9

Drugs requiring TDM ( Therapeutic Drug Monitoring) ?

Answer 9

Mnemonic- Look At TDM Concentration
L - Lithium
At - Aminoglycosides
Anti epileptic ( Phenytoin, Carbamazepine
Lamotrigene,Phenobarbit.)
T - TCA, Theophylline
D - Digoxin
M - Mtx
Conc. - calcinurin inhibitors ( Cyclosporin)

Question 10

Drugs acting on synthesis of qcetylcholine..

Answer 10

1. Hemicholinum
   2.Vasamicol
2. Aminoglycosidase
3. Beta-Bungarotoxin & Botulinum toxin

Question 11

GB neck guarded by…….

Answer 11

Valve of Heister

Question 12

Calot’s triangle

Answer 12

A smaller triangle within Cholecystohepatic triangle.

Boundaries:-
_Cystic artery
_Common hepatic duct
_Cystic duct

⭐Content - Lymph nodes of Lund
⬇️
1st LN to be enlarge in GB cancer

Question 13

Enz Inhibitors..

Answer 13

Mnemonic - VACINE

Verapamil
Amiodarone
Cyclosporine
Isoniazide (INH)
Nifedipine
Erythromycin

_inhibitors r Substrates of Pgp
_cause drug Toxicity

Question 14

Control of Perioperative Tachycardia

Answer 14

⭐Esmolol

_rapid onset
_half life 8 - 10 min
_Metabolism - by RBC esterase

Question 15

Org required synergistic effects of 2 antimicrobial…

Answer 15

Enterococcus fecalis

Penicillin + Aminoglycoside

_ bcz of Intrinsic resistance to penicillin

Question 16

Inducers

Answer 16

GPRS Cell Phone

Grisofulvin
Phenytoin
Rifampicin
Smoking
Carbamazepine
Phenobarbitone

Question 17

Enzyme Inhibitors

Answer 17

Vit - Valproate
K - Ketoconazole
Can - Ciprofloxacine
Cause - Cimetidine
Enz. - Erythromycine
Inhibitiin - INH