Pharm_Oncology Flashcards
What is the significance of a single living leukemic cell in the Skipper-Schabel model?
One living leukemic cell can be lethal to the host
To cure experimental leukemia, it is necessary to kill every leukemic cell in the mouse, regardless of number or distribution.
What does the Skipper-Schabel model state about the killing of leukemic cells by a drug?
The percentage, not the absolute number, of leukemic cell populations killed by a given dose is reasonably constant
This is known as the constant fractional (or percentage) drug kill phenomenon.
How is the percentage of leukemic cell populations killed related to drug dosage in the Skipper-Schabel model?
The percentage of leukemic cells killed by a single-dose treatment is directly proportional to the dose level of the drug
Higher doses result in higher percentages of cell kill.
Fill in the blank: In the Skipper-Schabel model, to cure leukemia, it is necessary to kill every _______ cell in the mouse.
leukemic
True or False: The Skipper-Schabel model suggests that the absolute number of leukemic cells killed is more important than the percentage killed.
False
What relationship does the Skipper-Schabel model describe between drug dosage and cell kill percentage?
Directly proportional
As the dose increases, the percentage of killed cells increases.
What is the Gompertzian Model of Tumor Growth?
A model that describes how the growth rate of tumor cells decreases with time.
It reflects the biological behavior of tumors as they progress and mature.
How does the growth rate of tumor cells change over time according to the Gompertzian Model?
The growth rate of tumor cells decreases with time.
This indicates that as tumors grow, their rate of proliferation slows down.
When is the response to chemotherapy most effective in the Gompertzian Model?
During the rapid growth phase of the tumor.
Chemotherapy targets rapidly dividing cells, making early treatment crucial.
What characterizes the plateau phase in tumor growth?
A period where the rate of tumor growth slows significantly.
This phase indicates that the tumor is reaching its maximum size or is under control.
Fill in the blank: The Gompertzian Model suggests that the _______ of tumor growth is rapid at first but slows down over time.
[rate]
True or False: The Gompertzian Model predicts that tumor growth rates remain constant over time.
False
The model indicates that growth rates decrease as the tumor matures.
What does the Goldie-Coldman Hypothesis state about tumor cells after treatment?
A fraction of tumor cells will develop resistance after treatment
This indicates that not all tumor cells are equally susceptible to therapy.
What happens to the resistant clone of tumor cells according to the Goldie-Coldman Hypothesis?
The clone will continue to grow even though the patient appears to respond
This can lead to treatment failure despite initial positive outcomes.
What is necessary to prevent the development of resistant clones in tumor treatment?
Alternating combinations of chemotherapy agents early in treatment is necessary
This strategy aims to reduce the likelihood of resistance development.
