PHARM_CDIFF

Question 1

what are the risk factors for C. Diff infection?

Answer 1

exposure to multiple abx (commonly with clindamycin-penicillins, cephalosporins-fluoroquinolones)
Hospitalization
Elderly pts
African American
IBD

Question 2

name the drug that causes pts to suffer from nausea and a metallic taste

Answer 2

metronidazole

Question 3

describe the use of metronidazole in pregnancy

Answer 3

not used in pregnancy, bc it crosses the placenta and is found in breast milk

Question 4

what is an adverse effect of metronidazole that hapens with high doses and prolonged use?

Answer 4

peripheral neuopathy

Question 5

how does fidaxomicin work?

Answer 5

inhibits bacterial RNA polymerases (macrolide antibiotic)

Question 6

how is fidaxomicin administered?

Answer 6

orally, stays in GI tract so doesnt have much systematization

Question 7

which antibiotic has no cross-resistance with other antimicrobials, including rifamycin?

Answer 7

fidaxomicin

Question 8

why don’t we use fidaxomicin much?

Answer 8

it’s expensieve, but it also works better in treating pts at high risk of Cdiff recurrence

Question 9

name the 3 drugs used to treat C. Diff infections?

Answer 9

metronidazole
vancomycin
fidaxomicin

Question 10

do fecal transplants work?

Answer 10

yes about 90% of pts reported clinical resolution, and there are no reported adverse events