PATHOPHYS Flashcards

1
Q

what are the only 2 hepatitis viruses that can cause acute hepatitis?

A

HAV, HEV

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2
Q

which hepatitis causes a more severe illness in pregnant women & elderly?

A

HEV

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3
Q

HAV, HBV vaccination should be given to all pts with what?

A

chronic liver disease

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4
Q

which 2 types of hepatitis viruses cause chronic hepatitis?

A

HBV, HCV

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5
Q

_________ (chronic hepatitis) can be effectively suppressed by current treatment, but cure is rare

A

HBV

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6
Q

which type of chronic hepatitis can be cured in a large percentage of pts?

A

HCV

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7
Q

which genotype of HCV is the hardest to cure?

A

Genotype 1 of HCV

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8
Q

all HBV pts should be screened for what?

A

HCC

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9
Q

if you have HCV and cirrhosis you should be screened for what?

A

HCC

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10
Q

what is the MCC of chronic liver dz in the US?

A

HCV

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11
Q

what is the 2nd MCC of chronic liver dz in the US?

A

Alcohol

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12
Q

what is the 3rd MCC of chronic liver dz in US?

A

NAFLD

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13
Q

what are the 2 most important environmental factors determining alcoholic liver disease risk?

A

ethanol & obesity

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14
Q

what is the genetic defect in hemochromatosis?

A

defective HFE gene (C282Y) on chromosome 6

unregulated Fe absorption in small intestine

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15
Q

what is the genetic defect in wilson’s disease?

A
ATPase enzyme (ATP7B gene) on chromosome 13
decreased loading of copper onto ceruloplasmin
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16
Q

what is the genetic defect in alpha1-antitrypsin deficiency?

A

failure to secrete alpha1-antitrypsin protein (chromosome 14), has abnormally folded molecule that gets stuck in liver cells and can’t get to lung and serum

17
Q

what is the screening test for hemochromatosis?

A

transferrin saturation

18
Q

what is the screening test for wilson’s disease?

A

ceruloplasmin and free copper levels

19
Q

what is the screening test for alpha1-antitrypsindeficiency?

A

alpha1-antitrypsin phenotype

20
Q

how do you diagnose hemochromatosis?

A

gene test (C282Y) mutation of HFE gene on chromosome 6

21
Q

how do you diagnose wilson’s disease?

A

liver biopsy

22
Q

how do you diagnose alpha1-antitrypsin deficiency?

A

liver biopsy

23
Q

what is the main organ problem in hemochromatosis?

A

cirrhosis of liver

24
Q

what is the main organ problem in wilson’s disease?

A

cirrhosis and fulminant liver failure

25
Q

what is the main organ problem in alpha1-antitrypsin deficiency?

A

cirrhosis of the liver

26
Q

what is the most common cause of cirrhosis?

A

alcoholic liver disease

27
Q

what is the most common cause of liver cirrhosis in children?

A

alpha1-antitrypsin deficiency

28
Q

name of pathology in liver dz with lack of return of renal function with intravascular volume repletion

A

hepatorenal syndrome

29
Q

what are the components of the child pugh score?

A
albumin
biirubin
ascites
encephalopathy
PT/INR
30
Q

what are the components of MELD?

A

INR
Bilirubin
creatinine

31
Q

what is the child pugh score used for?

A

can be used to determine prognosis after variceal bleeding

32
Q

what is the MELD score used for?

A

prognostic & preoperative sign, factor for transplant