Pharm- Target Therapies & Biologicals

Question 1

Bcr-Abl tyrosine kinase inhibitors

Answer 1

imatinib, dastinib

Question 2

Membrane Associated Receptor Tyrosine Kinases

Answer 2

Gefitinib, Erlotinib, Lapatinib, Sunitinib, Sorafenib

-tx of solid tumors that were driven by receptor tyrosine kinases

Question 3

Growth Factor Receptor Tyrosine Kinase Signaling

Answer 3

EGRF, PDGFR, VEGFR

Question 4

mutataed B-RAF kinase

Answer 4

Vemurafenib

Question 5

BCR-ABL drugs

Answer 5

dasatinib, imatinib

no antibodies

Question 6

EGRF-receptor drugs & Abs

Answer 6

Erolotinib, Gefitinib

Abs- Cetuximab, Panitumumab

Question 7

HER2-receptor drugs & Abs

Answer 7

Lapatinib

Ab- Trastuzumab

Question 8

PDGFR- receptor, VEGFR- receptor

Answer 8

Sunitinib, Sorafenib

-no antibodies

Question 9

VEGF-ligand Ab

Answer 9

Bevacizumab

Question 10

Angiogenesis inhibitors

Answer 10

Ab- Bevacizumab

RTK inhibitors- Sunitinib & sorafenib

Question 11

Antibodies to other epitopes

Answer 11

Rituximab- for CD20+ B cell lymphoma

Question 12

Bortezomib (IV)

Answer 12

26S proteasome target

• multiple myeloma, mantle cell lymphoma
• reactivation of varicella zoster

Question 13

Vorinostat (PO)

Answer 13

Histone deacetylase (HDAC) inhibitor

• Cutaneous T cell lymphoma
• pulmonary embolism, venous thrombosis

Question 14

Anastrazole

Answer 14

Aromatase inhibitor

-estrogen dependent breast cancer

Question 15

Exemestane

Answer 15

Aromatase inactivator

-advanced breast cancer

Question 16

Worst chemo drug offenders: CINV > 90%

Answer 16

carmustine, cisplatin, cyclophosphamide, dacarbazine, mechlorethamine
-all of these are mainly alkylating agents

Question 17

5-HT3 receptor antagonists

Answer 17

Ondansetron, Granisetron

• Cytotoxic durg
• emesis- acute

Question 18

Central acting Dopamine D2 receptor antagonists

Answer 18

Metoclopramide
Cytotoxic drug
-emesis- acute

Question 19

Neurokinin NK1 receptor antagonists

Answer 19

Aprepitant

• Cytotoxic drug
• emesis- delayed & acute

Question 20

Cannabinoid CB1 receptor agonist

Answer 20

Dronabinol
-cytotoxic drug
emesis- refractory to other agents

Question 21

antiemetic 5HT3 Receptor Antagonist

Answer 21

Ondansetron, Granisetron, Dolasetron, Palonosetron

Question 22

Ondansetron

Answer 22

IV, oral, oral dissolving tablet

t 1/2 = 4 hrs, hepatic metabolism

Question 23

Granisetron

Answer 23

IV, oral, transdermal patch
t 1/2= 10 hrs, hepatic metabolism
used for delayed emesis

Question 24

Dolasetron

Answer 24

oral only
t 1/2= 8 hrs, active metabolite
used for delayed emesis

Question 25

Palonosetron

Answer 25

IV, oral

t 1/2 =40 hrs, hepatic & renal elimination

Question 26

dexamethasone

Answer 26

potent glucocorticoid useful for acute & delayed emesis