Pharm-sepsis

Question 1

____ is recommended as the first choice vasopressor. Can add ____

Answer 1

Norepinephrine

Epinephrine or vasopressin

Question 2

Surviving Sepsis recommendations to be completed within 3 hours:
6 hours:

Answer 2

3: measure lactate, get blood cultures prior to broad spectrum abx, administer crystalloid for hypotension or lactate
6: vasopressors to maintain MAP >65mmHg, remeasure lactate if initial level was elevated

Question 3

Sepsis:
Abx:
Cell wall synthesis inhibitors

Answer 3

Penicillins
Cephalosporins
Vanc
Monobactams
Carbapenems

Question 4

Sepsis:
Abx:
DNA Gyrase inhibitors

Answer 4

Fluoroquinolones

Question 5

Sepsis:
Abx:
Protein synthesis inhibitors

Answer 5

Aminoglycosides

Question 6

Sepsis:

Other agents besides abx

Answer 6

1. Vasopressors (NE, Epi, Vasopressin, Dobutamine)
2. Diuretics (Furosemide)
3. Hydrocortisone
4. IV fluids

Question 7

Chelated with cations (Ca in milk, orange juice, etc)

Answer 7

Fluoroquinolones 
DNA inhibitors 
Ciprofloxacin
Moxi 
Levo

Question 8

Binds to Ca or Ca containing products ingested

Answer 8

Tetracyclines

Protein synthesis inhibitors

Question 9

Preferred agent for skin antisepsis

Answer 9

Chlorhexidine

Question 10

MOA of Chlorhexidine

Answer 10

Adsorbs to bacterial membranes causing leakage of small molecules and precipitation of cytoplasmic proteins

Question 11

Chlorhexidine is most effective against ___

Answer 11

Gram + cocci

Question 12

Spore germination is ____ by Chlorhexidine

Answer 12

Inhibited

Question 13

True or false: combo therapy is not recommended for ongoing tx of bacteremia, sepsis without shock, and neutropenic sepsis/bacteremia

Answer 13

True