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i&d quiz 2 > Pharm (Quiz 2) > Flashcards

Pharm (Quiz 2) Flashcards

1
Q

Herpesevirus drugs

A

acyclovir, ganciclovir, foscarnet (Herpesevirus)

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2
Q

Deoxyguanosine (dG) analog

A

acyclovir, ganciclovir (Herpesevirus)

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3
Q

Phosphorylated by viral thymidine kinase (TK)

A

acyclovir, ganciclovir (Herpesevirus)

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4
Q

Preferential incorporation by viral DNA polymerase

A

acyclovir, ganciclovir (Herpesevirus)

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5
Q

causes chain termination

A

acyclovir (Herpesevirus)

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6
Q

primary/chronic HSV/VZV infections

A

acyclovir (Herpesevirus)

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7
Q

CMV (Cytomegalovirus), Less so for HSV/VZV

A

Ganciclovir (Herpesevirus)

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8
Q

Generally well tolerated

A

acyclovir, ganciclovir (Herpesevirus)

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9
Q

bone marrow suppression

A

Ganciclovir (Herpesevirus)

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10
Q

activated by HSV/VZV thymidine kinase (TK)

A

acyclovir (Herpesevirus)

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11
Q

activated by HSV/VZV TK or CMV UL97 kinase

A

Ganciclovir (Herpesevirus)

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12
Q

Drug effective only in infected cells

A

acyclovir, ganciclovir (Herpesevirus)

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13
Q

Mutation in viral thymidine kinase or viral DNA polymerase (vPol)

A

acyclovir, ganciclovir resistance (Herpesevirus)

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14
Q

Pyrophosphate Analog

A

Foscarnet (Herpesevirus)

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15
Q

Binds to pyrophosphate site of viral polymerase (also RTase)

A

Foscarnet (Herpesevirus)

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16
Q

100-fold greater selective inhibitor of viral versus human polymerase

A

Foscarnet (Herpesevirus)

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17
Q

Acyclovir/ganciclovir resistant HSV/CMV

A

Foscarnet (Herpesevirus)

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18
Q

Hypocalcemia and CNS toxicity, Precipitates out Ca2+ and forms foscarnet-Ca2+ crystals

A

Foscarnet (Herpesevirus)

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19
Q

Nephrotoxicity

A

Foscarnet (Herpesevirus)

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20
Q

Mutation in viral DNA polymerase (vPol)

A

Foscarnet (Herpesevirus)

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21
Q

Hepatitis C drugs

A

paritaprevir, ledipasvir, ombitasvir, sofosbuvir (Hepatitis C)

22
Q

Influenza drugs

A

oseltamivir, amandatine, baloxavir (Influenza)

23
Q

Coronavirus drug

A

remdesivir (Coronavirus)

24
Q

Neurominidase inhibitor

A

oseltamivir (influenza)

25
Q

Blocks release of influenza virus from infected cells

A

oseltamivir (influenza)

26
Q

Treat influenza A and B

A

oseltamivir, baloxavir (influenza)

27
Q

Binds viral M2 protein that functions as an ion channel

A

amandatine (influenza)

28
Q

Prevents acidificaiton of viral core

A

amandatine (influenza)

29
Q

Blocks uncoating of virus in host cell

A

amandatine (influenza)

30
Q

Central nervous system toxicity

A

amandatine (influenza)

31
Q

Only treat influenza A;

Resistant strains has limited use

A

amandatine (influenza)

32
Q

Binds influenza PA protein and inhibits cap-dependent endonuclease activity

A

amandatine (influenza)

33
Q

Inhibits intiation of influenza RNA synthesis

A

amandatine (influenza)

34
Q

Inhibits Hepatitis C protease NS3/NS4A

A

Paritaprevir (Hepatitis C)

35
Q

Prevents processing of HCV polyprotein

A

Paritaprevir (Hepatitis C)

36
Q

Inhibits Hepatitis C NS5A phosphoprotein required for viral RNA synthesis and assembly

A

ledipasvir, ombitasvir (Hepatitis C)

37
Q

Inhibits Hepatitis C RNA polymerase NS5B

A

sofosbuvir (Hepatitis C)

38
Q

Blocks viral DNA synthesis

A

acyclovir, ganciclovir (Herpesevirus)

39
Q

Inhibits viral DNA polymerase and incorporates into DNA causing chain termination

A

acyclovir (Herpesevirus)

40
Q

Requires activation by viral “thymidine kinase”

A

acyclovir, ganciclovir (Herpesevirus)

41
Q

HSV/VZV treatment

A

acyclovir (Herpesevirus)

42
Q

Bone marrow depression

A

ganciclovir (Herpesevirus)

43
Q

CMV treatment

A

ganciclovir (Herpesevirus)

44
Q

Less selective for viral enzyme so more toxic than acyclovir

A

ganciclovir (Herpesevirus)

45
Q

Inhibits viral DNA polymerase activity

A

foscarnet (Herpesevirus)

46
Q

Binds pyrophosphate site of viral enzyme

A

foscarnet (Herpesevirus)

47
Q

Does NOT require kinase activation

A

foscarnet (Herpesevirus)

48
Q

Hypocalcemia; Can lead to seizures

A

foscarnet (Herpesevirus)

49
Q

Alternative when ganciclovir fails or acyclovir-resistant

A

foscarnet (Herpesevirus)

50
Q

Delayed viral RNA chain termination at postion +3

A

remdesivir (Coronavirus)

51
Q

Triphosphate form incorporated into viral RNA by RNA dependent RNA polymerase

A

remdesivir (Coronavirus)

52
Q

Prodrug; Used for adult and pediatric COVID patients requiring hospitalization

A

remdesivir (Coronavirus)

i&d quiz 2 (3 decks)

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