Pharm (Quiz 2) Flashcards
Herpesevirus drugs
acyclovir, ganciclovir, foscarnet (Herpesevirus)
Deoxyguanosine (dG) analog
acyclovir, ganciclovir (Herpesevirus)
Phosphorylated by viral thymidine kinase (TK)
acyclovir, ganciclovir (Herpesevirus)
Preferential incorporation by viral DNA polymerase
acyclovir, ganciclovir (Herpesevirus)
causes chain termination
acyclovir (Herpesevirus)
primary/chronic HSV/VZV infections
acyclovir (Herpesevirus)
CMV (Cytomegalovirus), Less so for HSV/VZV
Ganciclovir (Herpesevirus)
Generally well tolerated
acyclovir, ganciclovir (Herpesevirus)
bone marrow suppression
Ganciclovir (Herpesevirus)
activated by HSV/VZV thymidine kinase (TK)
acyclovir (Herpesevirus)
activated by HSV/VZV TK or CMV UL97 kinase
Ganciclovir (Herpesevirus)
Drug effective only in infected cells
acyclovir, ganciclovir (Herpesevirus)
Mutation in viral thymidine kinase or viral DNA polymerase (vPol)
acyclovir, ganciclovir resistance (Herpesevirus)
Pyrophosphate Analog
Foscarnet (Herpesevirus)
Binds to pyrophosphate site of viral polymerase (also RTase)
Foscarnet (Herpesevirus)
100-fold greater selective inhibitor of viral versus human polymerase
Foscarnet (Herpesevirus)
Acyclovir/ganciclovir resistant HSV/CMV
Foscarnet (Herpesevirus)
Hypocalcemia and CNS toxicity, Precipitates out Ca2+ and forms foscarnet-Ca2+ crystals
Foscarnet (Herpesevirus)
Nephrotoxicity
Foscarnet (Herpesevirus)
Mutation in viral DNA polymerase (vPol)
Foscarnet (Herpesevirus)