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I&D Quiz 2 > Histology: Thymus & Peripheral Lymphoid System (8.1) > Flashcards

Histology: Thymus & Peripheral Lymphoid System (8.1) Flashcards

1
Q

Lymphocytes:

A

B & T cells

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2
Q

Lymphocytes are formed in:

A

primary lymphoid organs

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3
Q

Primary lymphoid organs (2):

A

thymus & bone marrow

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4
Q

Naive mature lymphocytes are activated in:

A

secondary lymphoid organs & tissues

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5
Q

Secondary lymphoid organs (3):

A

lymph nodes, spleen, MALT

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6
Q

MALT:

A

TIPU (tonsils, Intestine/Peyer’s patches/appendix, Pulmonary/bronchiolar, Urinary/reproductive tract

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7
Q

Lymphocytes are derived from:

A

hematopoietic stem cell (HSC)

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8
Q

Dense packing of immature T cells (thymocytes):

A

cortex of thymus

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9
Q

Does not stain as intensely because there are fewer thymocytes and more framework or stromal cells:

A

central medullary

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10
Q

Intense eosinophilic structures in medulla of thymus:

A

Hassal’s bodies/corpuscles (collections of epithelial cells)

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11
Q

Thymus changes with age:

A

thymic involution

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12
Q

Chromosomal deletion disorder (chromosome 22q11.2 deletion syndrome) that results in poor development of several body systems, including thymic aplasia (a congenital absence of the thymus):

A

DiGeorge syndrome

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13
Q

DiGeorge syndrome is a type of:

A

severe combined immunodeficiency (SCID)

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14
Q

DiGeorge syndrome (a SCID) is often but not always characterized by:

A

cellular (T-cell) deficiency

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15
Q

Flow lymphatic system:

A

lymph capillary —> lymph node —> lymph trunk —> lymph duct

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16
Q

Injured or blocked lymphatic systems results in:

A

lymphedema

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17
Q

Environment where T and B cells encounter antigen:

A

lymph nodes

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18
Q

Site of plasma cell differentiation and antibody production:

A

lymph nodes

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19
Q

Most abundant location of lymph nodes:

A

axilla, groin (inguinal), along major vessels (neck, thorax, abdomen)

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20
Q

Lymph node structure:

A

dense connective tissue capsule

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21
Q

Afferent lymphatics enters on ___ side of lymph node:

A

convex

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22
Q

Efferent lymphatics enters on ___ side of lymph node:

A

concave

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23
Q

___ fibers in cortex serve as scaffolding and create niche for cells carry out their function:

A

reticular (type III collagen), stained with silver

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24
Q

B cell zone/follicle of lymph nodes:

A

cortex (outer)

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25
Q

T cell zone of lymph nodes:

A

paracortex (middle)

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26
Q

Cords and sinuses of lymph nodes:

A

medulla (inner)

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27
Q

Entry point for most lymphocytes into lymph nodes:

A

HEV (paracortex)

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28
Q

Antigen activated B cells within the follicle start dividing (proliferating) and elicit a ___ reaction:

A

germinal center

29
Q

After germinal center reaction, follicle is now:

A

secondary follicle

30
Q

Contains antigen activated, proliferating B cells that can differentiate to plasma cells or memory B cells:

A

lighter staining center of secondary follicle

31
Q

Assist B cell maturation in the germinal center:

A

T helper cells

32
Q

B and T cells that haven’t encountered their antigen are pushed to:

A

mantel zone (periphery)

33
Q

Highly proliferative B cells (plus their CD4+ T helper cells) that are undergoing somatic hypermutation:

A

Dark zone of germinal center

34
Q

B cells that have undergone somatic hypermutation to test their receptor binding and competition for interaction with antigen specific T cells:

A

light zone of germinal center

35
Q

Plasma cells leave the germinal center and migrate to:

A

medullary cord or bone marrow

36
Q

___ may remain in lymph node or recirculate:

A

Memory B cells

37
Q

Contains most of body’s lymphocytes:

A

GALT (gut associated)

38
Q

Tonsils covered with stratified squamous epithelium:

A

lingual, palatine

39
Q

Tonsils covered with pseudostratified columnar ciliated epithelium:

A

pharyngeal

40
Q

Covered by simple columnar epithelium with M cells:

A

Peyer patches

41
Q

Diffuse lymphoid tissue of lung:

A

BALT

42
Q

Largest single accumulation of lymphocytes:

A

spleen

43
Q

Organ responsible for defense against blood-borne antigens:

A

spleen

44
Q

Critical for removal of encapulated bacteria:

A

spleen

45
Q

Removal of senescent erythrocytes:

A

spleen

46
Q

Storage of platelets:

A

spleen

47
Q

Red pulp of spleen is responsible for:

A

blood filtration

48
Q

White pulp of spleen is responsible for:

A

immune responses

49
Q

Splenic cords and splenic sinusoids are location in:

A

red pulp of spleen

50
Q

Decline of immunity in elderly due to:

A

reducing size of thymus (and thus maturation of T cells)

51
Q

Blocks infections and eliminates extracellular microbes:

A

humoral immunity (adaptive)

52
Q

Elimination of phagocytose microbes:

A

cell-mediated immunity (adaptive)


53
Q

Kill infected cells and eliminated reservoirs of infection:

A

cell-mediated immunity (adaptive)

54
Q

B-lymphocytes are part of ___ immunity (adaptive):

A

humoral

55
Q

T-lymphocytes are part of ___ immunity (adaptive):

A

cell-mediated

56
Q

T-cells primarily make up this white pulp structure in the spleen:

A

PALS (Periarteriolar lymphoid sheath)

57
Q

Endothelial cells in splenic sinusoids:

A

stave

58
Q

Abbreviated name for lymphoid tissue found in and near the wall of the intestinal tract:

A

GALT

59
Q

Tonsils are covered by:

A

epithelium

60
Q

All leukocytes are derived from:

A

hematopoietic stem cell

61
Q

Medullary sinus in a lymph node drains into:

A

efferent lymph vessel

62
Q

Resident monocyte becomes ___ after it migrates to tissue:

A

macrophage

63
Q

Lymphatic organ that initiates an immune response to lymph-borne antigens:

A

lymph node

64
Q

Cells that form intracellular pocket to allow antigen from gut lumen to enter lymphatic system:

A

microfold

65
Q

Lymphatic tissue found on the back wall of the nasopharynx:

A

adenoid

66
Q

Dome-like aggregates of lymphocytes make up prominent gut mucosa associated lymphoid tissues:

A

Peyer’s patches

67
Q

Reticular fibers are made of:

A

Collagen

68
Q

Encapsulated, primary lymphatic organ:

A

thymus

69
Q

Medullary cords in lymph nodes are formed by T, B, and ___ cells:

A

plasma

I&D Quiz 2 (3 decks)

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